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ЗмістThe specific objectives The objectives of the entry-level
Self and self-knowledge of the initial skills.
Flow chart classes
The algorithm of morphological diagnosis of fatty degeneration of parenchymal
Ultrastructural pathology of cells. Of damage. Parenchymal dystrophy.
Relevance of the topic: The basis of many pathological processes are changes in the ultrastructure of cells. These changes occur under the influence of many damaging environmental factors - a variety of biological, chemical and physical agents under vozdystviem hypoxia, congestion, and the resulting changes in the inheritance of the genetic apparatus. they are often stereotyped and show how the process of damage and adaptation processes, adaptation and compensation for damaged structures. Knowing their need for understanding many processes obschepatologicheskih and diseases. Also, very often Injurious eniya parenchyma cells, which leads to a decrease in organ function and form the basis of many diseases to be studied in our and other medical disciplines.
The purpose of (total): be able to represent the essence of the ultrastructural changes of cells in lesions and other pathological processes, understand the causes and mechanisms of parenchymatous dystrophy, to be able to macro-and microscopic manifestations distinguish between types of parenchymatous dystrophy, treated their outcomes and value for the organism.
Be able to:
In order for you to understand as to whether the initial level of your knowledge, skills required, we offer a number of tasks to perform.
Target number 1. With electron-microscopic study of cells in its cytoplasm, membranous vesicles found small size of about 0.2-0.5 microns, filled structureless substance containing hydrolases. On what organelle do you mean?
Task number 2. Microscopic examination of tissue viyavleno that her unit has srtrukturnaya hexagonal prism shape, bounded by two vessels and the duct. In the center of Vienna is located, into which sinusoidal capillaries, the cells form a beam. What is the authority?
Task number 3. Nephron - a structural and functional unit of the kidney. What is included in its composition?
Target number 4. Body consists of cells with elongated, their ends are connected to each other, so that chains of cells are functional fibers. In the center, the cells have oval nuclei located in the cytoplasm of myofibers. As these cells are called?
Standards of responses to the solutions of jobs for self-examination and self-knowledge source-level skills: 1.-4, 2.-1, 3.-1, 4-2.
Information necessary for knowledge, skills can be found in the following literature:
The content of education should achieve the goals of education, which promotes thethere exists a graph-logical structure of the theme: "The ultrastructural pathology of cells. Damages. Parenhimatoznіye dystrophy." (Appendix № 1) Theoretical issues on which you can do the task activities.
Books for learning the required knowledge, skills on this topic:
After examining the above tasks for self-mastery of the material on the subject predlagaetsya the following targets.
Vipolnite following targets
Target number one. According electron microscopy, the nuclei of the tumor increased several times, their chromatin compact, kondensovany. The amount of DNA in two, three, four or more times higher than it in normal tissue. This is evidence of:
Task number 2. In the plasma cell, which actively synthesize immunoglobulins increased cytoplasm, the nucleus is displaced to the periphery. By increasing public ultrastructures did this happen?
Task number 3. Coronary heart disease, was found microscopically plot, in which cardiomyocytes increased in all sizes, with a pale, clear cytoplasm, which resembles lace, Schick-negative. Nuclei little changed. What is the diagnosis?
Target number 4. The child died of diphtheria, endocarditis in the heart of a band of yellow found on a red background infarction. Myocardium resembles the "skin of a tiger." What is the diagnosis?
Task number 5. A child bolevshego salmonelezom at autopsy revealed a large liver is light brown in color. Large areas of yellow.
What is the process in the liver rozvilsya?
Target number 6. In a patient with viral hepatitis B, microscopic examination of liver biopsy punktsinnogo found enlarged hepatocytes, the cytoplasm of which is light, like lace. In the PAS-reaction of glycogen in them is reduced. What is the pathological process in hepatocytes?
Target number 7. Patient 35 years old, was admitted to the intensive care unit with ethylene glycol poisoning, acute renal failure from which he died. Microscopic examination of renal tubule, the cells has increased dramatically, the cytoplasm is light, frothy, like lace. What type of degeneration in the epithelium of the tubules of kidneys?
Target number 8. At autopsy the patient died of sepsis with severe intoxication, found "tiger heart". In the histochemical study in the cytoplasm of cardiomyocytes detected lipids. What is the most probable mechanism of this degeneration?
Target number 9. The man on the oral mucosa was found a white spot. With electron-microscopic study in the cytoplasm of cells, a sharp increase in Number of filamentary shape ultrastructures formed by keratin. At some sites, many of them turn into keratohyalin. For what type of parenchymatous degeneration is characterized by?
Guidelines for student work on a practical lesson: "The ultrastructural pathology of cells. Damages. Parenchymal dystrophy."
In early studies on the standards of answers Be sure homework solutions. Then, by means of test control will be tested to prepare your lesson.
You must learn self-diffraction, macro-and micropreparations, solve situational tasks. The macroscopic features of parenchymatous dystrophy study on drugs "fatty liver", "tiger heart". Using micropreparations ofuchayut morphological manifestations of various dystrophies, Histochemical methods for detecting them, "vacuolar degeneration of tubular epithelial buds," "fatty liver" - painting with hematoxylin-eosin, and fat with Sudan 3-4. It uses "The algorithm of the microscopic diagnosis of vacuolar and fatty degeneration" (Appendix 2), "An algorithm describing makropreparatov" (Appendix 3).
Session ends with an analysis of the results of independent work of each student by checking the description micropreparations, testsOn the control of learning.
Count the logical structure of the theme: "Damage. Parenchymal dystrophy. "
Damage to the lysosomes
A reversible process
exogenous .- glycols
General characteristics of hyaline droplets, horny dystrophy
A reversible process
Micro-and macroscopic changes
The concept of glycogenosis
Morphological changes in the kidney in diabetes mellitus
Supplement number 2
Enlarged, flabby, the cut, the fabric is striped, yellow color band under endokardom. kind of "tiger heart"
Enlarged, flabby, dull crust with a touch of Zsolt
Increased, clay type, flabby, dull
In the cytoplasm miokardiotsitov deposition of droplets of fat (Sudan III staining, etc.), round clear vacuoles in normal preparations
In the cytoplasm of hepatocytes deposition of droplets of fat. Round clear vacuoles in normal preparations
In the epithelium of the convoluted tubules droplets of fat. Round clear vacuoles in normal preparations
Fatty degeneration of parenchymal
Supplement number 3
The algorithm description makropreparatov
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1. /Topic 1 st admission departm.doc
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2. /Topic 02.doc
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2. /Topic 02.doc