3395 Krok-1 Pharmacology icon

3395 Krok-1 Pharmacology




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3. The conduction anaesthesia was given to patient before tooth extraction. In several minutes after this the oedema and hyperaemia had developed around injection site; the general weakness and hypotension had developed in patient. Determine the described complication.

A. Idiosyncrasy.

B. Tolerance.

C. Tachyphylaxis.

D. Drug dependence.

*E. Allergic reaction.

4. These drugs cause the coagulation of mucous proteins, condense the superficial surface of mucous membranes, and display anti-inflammatory action. What is this group of drugs?

A. Adsorbing drugs.

B. Local anaesthetics.

C. Irritative drugs.

D. Covering drugs.

*E. Astringent drugs.

5. This drug has low solubility in water; therefore it is used for terminal anaesthesia in ointments, pastas, powders, candles. Also it is prescribed in powders for internal use in stomach pain and vomiting. Indicate this drug.

A. Lidocaine.

B. Procaine (novocainum).

C. Tetracaine (dicainum).

D. Trimecaine.

*E. Benzocaine (anaesthesinum).

6. A patient has heart pain for some time, which is not connected to physical loading. Call the irritative substance which narrows the vessels of mucous in local use, and causes reflex expansion of coronary vessels.

A. Sinapisms.

B. Ammonia solution.

C. Turpentine oil.

D. Camphor.

*E. Menthol.

7. Combine operator had received the eye trauma during crop harvest. What local anaesthetic should be used for removal of foreign body from eye?

A. Sovcainum.

B. Procaine (novocainum).

C. Lidocaine.

D. Trimecaine.

*E. Tetracaine (dicainum).

8. A doctor made the sensitivity test to novocainum in patient before the infiltration anaesthesia. The test is positive. What drug should be used for infiltration anaesthesia to this patient?

A. Cocaine.

B. Novocainamide.

C. Dicainum.

D. Anaesthesinum.

*E. Lidocaine.

9. A patient with abscess of shoulder was delivered to the surgery department. During examination a doctor has found out ventricular extrasystoles. What type of anaesthesia is most expedient in this patient?

A. General anaesthesia with ketamine.

B. Spinal anaesthesia with sovcainum.

C. General anaesthesia with hexenalum.

D. General anaesthesia with ether pro narcosis.

*E. Local anaesthesia with lidocaine.

10. A patient with acute attack of appendicitis was delivered to surgery unit. An anaesthesiologist suggested local anaesthesia for operation. But during examination it became clear that the patient has the frequent allergic reaction upon the drugs. Choose the drug which can be used for local anaesthesia in this case.

A. Novocainum.

B. Anaesthesinum.

C. Dicainum.

D. Cocaine.

*E. Lidocaine.

11. The terminal anaesthesia develops in the result of drug influence upon the following element of skin and mucous membranes:

A. Derma.

B. Epidermis.

C. Hypodermic fatty tissue.

D. Capillaries wall.

*E. Sensitive nervous ending.

12. A patient needs performing of paranefral Vishnevsky’s blockade. What concentration of novocainum solution is used in this case?

A. 4–5%.

B. 0.5–1%.

C. 1–2%.

D. 2–4%.

*E. 0.125–0.5%.

13. A patient with high sensitivity to sulfonamides had appealed to the ophthalmic department with trauma of eye. What drug should be used for anaesthesia of conjunctiva in this case?

A. Anaesthesinum.

B. Novocainum.

C. Trimecaine.

D. Dicainum.

*E. Lidocaine.

14. Call the drug from group of local anaesthetics which is not desirable to prescribe simultaneously with sulfonamides.

A. Ultracaine.

B. Anaesthesinum.

C. Lidocaine.

D. Trimecaine.

*E. Novocainum.

15. A doctor has prescribed an ointment “Efcamonum” to patient. This ointment is irritative drug according to mechanism of action. Indicate the case, in which “Efcamonum” is contraindicated.

A. Neuritis.

B. Neuralgia.

C. Pain in a joint.

D. Myalgia.

*E. Skin injury.

16. The action of novocainum is decreased in areas of inflammation because the disturbance of hydrolysis of novocainum salt and releasing of active basic substance develop. What is the cause of this phenomenon?

A. Inhibition of oxidative phosphorylation.

B. Local tissue alkalosis.

C. Inhibition of carboanhydrase.

D. Activation of succinate dehydrogenase.

*E. Local tissue acidosis.

17. A third-year student during the practice should put the sinapisms on the back of patient. For this purpose he has moistened the sinapisms with very hot water (the temperature is more than 60 0C). In 30 minutes the student has found out that the skin of patient has not reddened in place of applied sinapisms. What is the cause of this phenomenon?

A. Hot water causes activation of MAO.

B. Hot water causes inactivation of cholinesterase.

C. Hot water causes activation of mirosine.

D. Hot water causes inactivation of MAO.

*E. Hot water causes inactivation of mirosine.

18. A 25-year-old woman with red and itchy eczematoid dermatitis visits your office. She had a dental procedure one day earlier with administration of local anaesthetic. There were no other findings, although she indicated that she had a history of allergic reactions. Which of the following drugs is most likely involved?

A. Cocaine.

B. Bupivacaine.

C. Lidocaine.

D. Etidocaine.

*E. Procaine.

19. A patient with an abscess was admitted to a surgical department for operative treatment. During additional examination ventricular premature beats were detected. What drug is the most expedient for anaesthesia in this case?

A. Ketamine.

B. Halothane (phthorothanum).

C. Hexenal.

D. Aether pro narcosi.

*E. Lidocaine.


^ Cholinomimetic Drugs and

Cholinesterase Inhibitors


1. During operation the anaesthesiologist has overdosed tubocurarine chloride to patient. Proserine has been prescribed. What is the base of action proserine in this case?

A. Blockade of adrenoceptors.

B. Increase of cholinesterase activity.

C. Blockade of presynaptic membrane.

D. Stimulation of M-cholinoceptors.

*E. Inhibition of cholinesterase activity.

2. A patient is delivered into hospital with complaints of dizziness, decrease of vision acuteness, nausea, hypersalivation, and abdominal cramps. The diagnosis is poisoning with organophosphorus compounds. What drugs should be included in complex therapy?

A. Glucose and bemegride.

B. Thiosulfate sodium and bemegride.

C. EDTA.

D. Naloxone and bemegride.

*E. Atropine sulfate and dipyroxime.

3. A patient with complaints of dry mouth and skin, vision disturbances, mydriasis, and tachycardia has been delivered into hospital. The doctor has put the diagnosis of poisoning with belladonna alkaloids. What drug should be prescribed?

A. Dipyroxime.

B. Aceclidine.

C. Pilocarpine.

D. Armine.

*E. Neostigmine (proserinum).

4. Residual phenomena is observed in a child after poliomyelitis. What drug should be prescribed in this case?

A. Pyrroxane.

B. Pentamine (azamethonium).

C. Dimecoline.

D. Atropine sulfate.

*E. Galanthamine.

5. A victim processed the plant by insecticides without the individual means of protection. After some time the following symptoms were developed in him: hypersalivation, sweating, diarrhoea, miosis, and pain in the abdomen. The drug, which has caused this poisoning, is included to the group of:

A. Organic chloride compounds.

B. N-cholinomimetics.

C. Cuprum salts.

D. Nitrates.

*E. Cholinesterase inhibitors.

6. After the dropping of drops of some drug into eyes the miosis and short-sightedness has developed in patient with glaucoma. The intraocular pressure has decreased. What group of drug can cause such effect?

A. Ganglioblockers.

B. M-cholinoblockers.

C. -Adrenomimetics.

D. N-cholinomimetics.

*E. M-cholinomimetics.

7. Paresis of intestine has developed in patient after surgery. What drug from group of cholinesterase inhibitors should be prescribed to this patient?

A. Acetylcholine.

B. Carbacholine.

C. Aceclidine.

D. Pilocarpine.

*E. Neostigmine (proserinum).

8. A 5-year-old child has been delivered to emergency department with the following symptoms: marked psychomotor excitation, delirium, hallucinations, hoarse voice, dilatation of pupils, hyperaemia of the skin, tachycardia, and tachypnoea. These symptoms were developed after the child has used the berries of belladonna. What group of drug should be prescribed for treatment of the child?

A. Cholinesterase regenerators.

B. N-cholinomimetics.

C. M-cholinomimetics.

D. N-cholinoblockers.

*E. Cholinesterase inhibitors.

9. The disturbances of breathing had developed in patient during the operation with the use of peripheral myorelaxants. The administration of proserinum improves the patient’s condition. What is such interaction of drugs called?

A. Cumulation.

B. Synergism.

C. Incompatibility.

D. Tachyphylaxis.

*E. Antagonism.

10. A 4-year-old boy was delivered to toxicological department with poisoning by berries of belladonna. What drug should be prescribed to boy in this condition?

A. Platyphyllin.

B. Aceclidine.

C. Lobeline.

D. Cytitonum.

*E. Galantamine.

11. The peristaltic of intestine was not restored in patient after resection of stomach. What drug should be prescribed to patient for stimulation of GI-tract function?

A. Succinylcholine (dithylinum).

B. Platyphyllin.

C. Cyclodol.

D. Atropine.

*E. Neostigmine (proserinum).

12. A patient with complaints of weakness and disturbances of gait came to the doctor. The doctor has diagnosed myasthenia and prescribed to the patient the injection of proserinum. What is the mechanism of proserinum action?

A. Activation of acetylcholine synthesis.

B. Direct stimulation of cholinoceptors.

C. Stimulation of metabolic processes.

D. Inhibition of brake processes.

*E. Inhibition of cholinesterase.

13. A 40-year-old male was delivered to toxicological department with poisoning by insecticides. What cholinesterase regenerator drug should be prescribed to patient?

A. Atropine.

B. Platyphyllin.

C. Scopolamine.

D. Amizylum.

*E. Dipyroxime.

14. What drug, which can cause miosis, will keep the action in animal with denervation of smooth muscles of eye?

A. Reserpine.

B. Galantamine.

C. Proserinum.

D. Prazosin.

*E. Pilocarpine.

15. A female was receiving injections of galantamine for restoration of CNS functions after ischaemic stroke. The condition of female significantly improved. What is the mechanism of this drug action?

A. Blockade of monoamine oxidase.

B. Blockade of cholinoceptors.

C. Blockade of catechol-ortho-methyltransferase.

D. Blockade of dopaminehydroxylase.

*E. Blockade of cholinesterase.

16. A 65-year-old male is accepted in neurological department with postinsult syndrome. What drug should be prescribed for acce-leration of this patient’s recovery?

A. Aceclidine.

B. Ipratropium bromide.

C. Dipyroxime.

D. Isonitrosine.

*E. Galantamine hydrobromide.

17. Drug A. was prescribed to patient with myasthenia and caused the improving of muscles activity. But several side effects had developed gradually: hypersalivation, sweating, diarrhoea, nausea. What drug was used for treatment of the patient?

A. Armine.

B. Metamizole (analginum).

C. Strychnine.

D. Caffeine.

*E. Neostigmine (proserinum).

18. A physician has prescribed eye drops with proserinum to patient for decrease of intraocular pressure. What is the mechanism of proserinum action?

A. Blockade of phospholypase.

B. Blockade of cyclooxygenase.

C. Blockade of lipoxygenase.

D. Blockade of phosphodiesterase.

*E. Blockade of cholinesterase.

19. The victim was delivered to emergency department with complaints of dryness in mouth, photophobia, and disturbances of vision. Hyperaemia, dryness of skin, and tachycardia are observed. The diagnosis is the poisoning with belladonna alkaloids. What drug should be prescribed?

A. Dipyroxime.

B. Diazepam.

C. Pilocarpine.

D. Armine.

*E. Proserinum.

20. The atony of intestine has developed in patient on the 3rd day after resection of stomach. What drug should be used?

A. Pirilenum.

B. Atropine sulfate.

C. Hexamethonium (benzohexonium).

D. “No-spa” (drotaverine).

*E. Proserinum.

21. A 2-year-old child has had a drink of eye drops from the first-aid set. The child has significant sweating and hypersalivation, difficult breathing, and cough. The pupils are narrowed and bradycardia is observed. The peristaltic of intestine is increased. The blood pressure is low. What drug has caused poisoning?

A. Sulfacetamide (sulfacylum-sodium).

B. Propranolol (anaprilinum).

C. Atropine.

D. Platyphyllin.

*E. Pilocarpine hydrochloride.

22. A patient was delivered to emergency department with such symptoms: miosis, hypersalivation, sweating, vomiting diarrhoea, and spasm of bronchi. The diagnosis of poisoning with organophosphorus substances was ascertained. What drugs should be included in complex therapy?

A. Panangin and unithiole.

B. Thiosulfate sodium and bemegride.

C. Nalorphine hydrochloride and bemegride.

D. Glucose and bemegride.

*E. Atropine sulfate and dipyroxime.

23. Analeptical remedy of reflective type from the H-cholinomimetics group was given to the patient for restoration of breathing after poisoning with carbon monooxide. What medicine was prescribed to the patient?

A. Atropine sulfate.

B. Phenylephrine (mesatonum).

C. Adrenaline hydrochloride.

D. Pentamine.

*E. Lobeline hydrochloride.

24. A 50-year-old male farm worker has been brought to the emergency room. He was found confused in the orchard and since then has remained unconscious. His heart rate is 45 and his blood pressure is 80/40 mm Hg. He is sweating and salivating profusely. Which of the following should be prescribed?

A. Pentamine.

B. Proserinum.

C. Physostigmine.

D. Noradrenaline.

*E. Atropine.

25. A child has residual phenomena after poliomyelitis. What drug is to be prescribed?

A. Pyroxanum.

B. Pentamine.

C. Dimecolinum.

D. Atropine sulfate.

*E. Galanthamine hydrobromide.

26. An injection of galanthamine hydrobromide was made to a woman, 63-year-old, after ischaemic stroke. Condition of the patient has considerably improved. What is the mechanism of this medication effect?

A. Inhibition of monoamine oxidase.

B. Inhibition of cholinergic receptors.

C. Inhibition of catechol-orto-methyltranspherase.

D. Inhibition of dopamine-hydroxylase.

*E. Inhibition of acetylcholinesterase.

27. It is necessary to prescribe a medication to a patient with glaucoma diagnosis. Which anticholinesterase drug (tertiary amine) isn’t used in ophthalmologic practice due to its irritative influence on the eye conjunctiva?

A. Armine.

B. Pyridostigmine bromide.

C. Phosphacol.

D. Proserinum.

*E. Galanthamine hydrobromide.

28. A patient with myasthenia was prescribed a drug which improved muscle performance. But a number of defects have been revealed gradually: intensive salivation, transpiration, diarrhoea, nausea. What drug was used for treatment?

A. Armine.

B. Analginum.

C. Strychnine nitrate.

D. Caffeine sodium benzoate.

*E. Proserinum.

29. A 25-year-old man appeals to neurologist with complaints of weakness in legs and gait disorder. The doctor diagnoses myasthenia and prescribes to patient an injection of proserinum. What is typical action of this drug?

A. Activation of acetylcholine synthesis.

B. Direct cholinomimetic.

C. Stimulation of metabolic processes.

D. Ganglion blocking.

*E. Prevention of acetylcholine destruction.

30. A child poisoned with mushrooms, namely fly agarics, has been taken to a toxicological department. What drug should be used for emergency first of all?

A. Dipiroxime.

B. Papaverine hydrochloride.

C. Unithiole.

D. Sodium thiosulfate.

*E. Atropine sulfate.

31. A 2-year-old child has drunk eye drops from the domestic first-aid kit. The child’s condition is poor, accompanied by transpiration and salivation, asthmatic breathing, cough, sharply miotic pupils, muffled heart sounds, bradycardia, low arterial pressure, intensive intestinal peristalsis, diarrhea. What is the drug which has caused the poisoning?

A. Sulfacylum-natrium.

B. Propranolol.

C. Atropine sulfate.

D. Platyphylline hydrotartrate.

*E. Pilocarpine hydrochloride.

32. A victim treated plants with an insecticidal solution without personal protection equipment. After a while, salivation, transpiration, tears secretion, pain in the stomach, and diarrhoea began. Examination revealed miosis. What group does the substance, which has caused such symptoms, belong to?

A. Organic compounds of chlorine.

B. N-cholinomimetics.

C. Copper salt.

D. Nitrates.

*E. Organic compounds of phosphorus.

33. Having used eye drops, a patient with glaucoma has developed miosis and myopia, intraocular pressure has decreased. What group of drugs causes such effect?

A. Ganglionic blockers.

B. M-cholinergic blockers.

C. -Adrenergic blockers.

D. N-cholinomimetics.

*E. M-cholinomimetics.

34. An 18-year-old unconsciousness patient was delivered to urgent unit with signs of dry skin and widened pupils. It is known, that patient has poisoned with berries of belladonna containing M-cholinoblocker atropine. What drug should be prescribed to the patient?

A. Platyphyllin.

B. Adrenaline.

C. Pilocarpine.

D. Propranolol (anaprilinum).

*E. Proserinum.

35. A victim with acute poisoning by fly-agaric was delivered to urgent department. What drug should be prescribed to him?

A. Omeprazole.

B. Dithylinum.

C. Diazolinum.

D. Furacilinum.

*E. Atropine sulfate.

36. The agent which decreases intraocular pressure is prescribed to patient with glaucoma. Indicate this agent.

A. Penicillin.

B. Noradrenaline.

C. Phenazepam.

D. Analginum.

*E. Proserinum.

37. Paralysis of bladder muscles has developed in patient owing to surgery. What group of drugs should be prescribed to this patient?

A. Antianginal drugs.

B. Diuretics.

C. Antibiotics.

D. Adrenoblockers.

*E. Cholinesterase inhibitors.


^ M-Cholinoblocking Drugs


1. Laryngospasm and hypersalivation have developed in patient after introduction of thiopental sodium for initial anaesthesia. The previous introduction of what drug can prevent the development of these side effects?

A. Epinephrine hydrochloride.

B. Proserinum.

C. Alloxime.

D. Pyrroxanum.

*E. Atropine sulfate.
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