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3395 Krok-1 Pharmacology

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13. A 50-year-old female suffers from hypertensibe disease and ulcer disease of stomach with increased production of hydrochloric acid. Indicate drug, which is contraindicated to this patient for treatment of hypertensive disease.

A. Nifedipine (fenigidin).

B. Dibazol.

C. Spironolactone.

D. Furosemide.

*E. Reserpine.

14. A 50-year-old patient suffers from ischaemic heart disease, сiliary arrhythmia, and cardiosclerosis. Choose the drug, which is necessary to prescribe to this patient.

A. Potassium chloride.

B. Acetylsalicylic acid.

C. Digoxin.

D. Strophanthine.

*E. Metoprolol.

15. A patient who suffers from hypertensive disease of the
I stage, took drug A. in tablets. In several weeks he began feeling pain in stomach, nausea, apathy, sleepiness. What drug is the cause of these adverse effects?

A. Captopril.

B. Chlorothiazide (dichlothiazidum).

C. Octadinum.

D. Fenigidin.

*E. Reserpine.

16. It is necessary to prescribe antiarrhythmic drug to patient who suffers from сiliary arrhythmia and bronchial asthma. Indicate antiarrhythmic drug which is contraindicated to this patient.

A. Novocainamidum (procainamide).

B. Ajmalin.

C. Verapamil.

D. Nifedipine.

*E. Anaprilinum (propranolol).

17. Anaprilinum therapy caused positive effect in the dynamic of the disease of 44-year-old woman suffering from stenocardia. What is the main mechanism of the effect of this drug?

A. Decrease of oxidative exchange in myocardium due to enzyme blockade of Krebs cycle.

B. Increased oxygen supply to the myocardium.

C. Decreased power inputs of myocardium due to reduced loading.

D. Decreased need in increasing of oxygen supply to the myocardium.

*E. Blockade of -adrenoceptors and decrease of myocardial requirements to the oxygen.

18. Propranolol has been prescribed to a 36-year-old female patient suffering from ischaemic heart disease. But the doctor decided to replace this drug by atenolol due to concomitant disease. What disease was found by the doctor?

A. Cholecystitis.

B. Arterial hypertension.

C. Duodenal ulcer.

D. Myasthenia.

*E. Bronchial asthma.

19. A 60-year-old woman, suffering from toxic goiter, complains of constant palpitation. What drug should be prescribed for normalization of heart rate?

A. Pentamine.

B. Isadrinum.

C. Salbutamol.

D. Adrenaline hydrochloride.

*E. Propranolol.

20. For the treatment of angina a selective 1-adrenergic blocker, which has no internal sympathomimetic activity, was prescribed. It is known that the drug is lipophilic, has average duration of action and is produced in tablets and ampoules. What is this drug?

A. Propranolol.

B. Talinolol.

C. Benzohexonium.

D. Drotaverine.

*E. Metoprolol.

21. Therapy with propranolol has positively affected the course of the disease of a 44-year-old woman with angina pectoris. What is the mechanism of antianginal action of this drug?

A. Decrease of the need for oxygen and increase of the coming of oxygen into the myocardium.

B. Decrease of the oxidative exchange in the myocardium due to the inhibition of the enzymes of Krebs cycle.

C. Decrease of myocardium energy consumption due to the decrease of load.

D. Increase of oxygen coming into the myocardium.

*E. Inhibition of 1-adrenoceptors and decrease of the need of the myocardium for oxygen.

22. A patient suffering from ischaemic heart disease did not inform the doctor about the attacks of bronchospasm he sometimes had, the doctor prescribed a drug, the intake of which made the attacks of angina pectoris less frequent, but the attacks of bronchospasm became more frequent. What drug has been prescribed?

A. Diltiazem.

B. Verapamil.

C. Nitrosorbide.

D. Nitroglycerin.

*E. Propranolol.

23. For the treatment of ischaemic heart disease a patient has been given -adrenoreceptor antagonist. After a while he had a cough and bronchospasm. Which of the drugs has such evident side action?

A. Metoprolol.

B. Talinolol.

C. Atenolol.

D. Nifedipine.

*E. Propranolol.

24. Bronchoconstriction has developed in hypertensive patient after reception of drug. What drug causes bronchoconstriction?

A. Isosorbide mononitrate.

B. Nitroglycerin.

C. Corglycon.

D. Amiodarone.

*E. Propranolol.

25. Antihypertensive agent has decreased the blood pressure during first several days of treatment owing to diminish of minute heart volume. In four weeks of using, minute heart volume restored to initial level but blood pressure had remained low. Indicate drug which is used in this case.

A. Losartan.

B. Prazosin.

C. Methyldopa.

D. Octadinum.

*E. Anaprilinum.

26. Drag A. is prescribed to patient with ischaemic heart disease for prevention of angina attacks. Indicate this drug.

A. Furosemide.

B. Atropine sulfate.

C. Morphine.

D. Oxytocin.

*E. Metoprolol.

27. A patient with hypertensive disease is delivered to cardiologic department. The doctor prescribed him the hypotensive drug which blocks both 1- and 2-adrenoceptors. Indicate this drug.

A. Indomethacin.

B. Proserinum.

C. Celecoxib.

D. Prednisolone.

*E. Anaprilinum.

28. A patient with coronary artery disease was admitted to the cardiological department. For stenocardia prevention a drug from the group of β-adrenoceptor blockers was administered. What drug is it?

A. Atropine sulfate.

B. Morphine hydrochloride.

C. Oxytocin.

D. Furosemide.

*E. Metoprolol.


General Anaesthetics

1. Proserinum in case of systemic administration increases the tone of skeletal muscles. Phthorotanum (halothane) causes relaxation of skeletal muscles and decreases the effects of proserinum. Call the character of interaction with proserinum and phthorotanum.

A. Noncompetitive antagonism.

B. Direct functional antagonism.

C. Competitive antagonism.

D. Independent antagonism.

*E. Indirect functional antagonism.

2. An anaesthesiologist has used nitrous oxide as general anaesthetic during operation. This drug has significant solubility in lipids. Indicate the mechanism of penetration of this drug through biological membranes.

A. Pinocytosis.

B. Active transport.

C. Simplified diffusion.

D. Filtration.

*E. Passive diffusion.

3. To anaesthetize the manipulation related to burn surface treatment, a patient was intravenously injected a drug for short-acting narcosis. A minute later increased blood pressure, tachycardia, increased tone of skeletal muscles; reflexes remained. After awakening the patient had disorientation and visual hallucinations. What drug was injected to patient?

A. Nitrous oxide.

B. Sombrevin.

C. Diethyl ether.

D. Thiopental sodium.

*E. Ketamine.

4. Proserinum increases skeletal muscle tone when given systematically. Halothane induces relaxation of skeletal muscles and reduces proserin effects. What is the nature of proserinum and halothane interaction?

A. Indirect functional antagonism.

B. Noncompetitive antagonism.

C. Competitive antagonism.

D. Direct functional antagonism.

*E. Independent antagonism.

5. For inithial anaesthesia, anaesthesiologist administers thiopenthal sodium to patient. Owing to this, hypersalivation and laryngospasm are developed in patient. Which drug can prevent these complications?

A. Salbutamol.

B. Adrenaline.

C. Proserinum.

D. Ephedrine.

*E. Atropine.

6. For general anaesthesia, anaesthesiologist uses combination of inhaled anaesthetic and derivative of barbituric acid. Choose this combination.

A. Droperidol and ether.

B. Promedolum and halothane.

C. Nitrous oxide and ketamine.

D. Halothane and fentanyl.

*E. Thiopenthal sodium and halothane.

7. Acute hepatitis developed in patient after surgery with reuse of sorting general anaesthetic. Which anaesthetic drug is used?

A. Ether.

B. Nitrous oxide.

C. Thiopenthal sodium.

D. Propanidid.

*E. Halothane (phthorotanum).

8. Anaesthesiologist administers to a patient general anaesthetic with prolonged phase of the excitation. Which drug is administered?

A. Oxybutirate sodium.

B. Phthorotanum (halothane).

C. Nitrous oxide.

D. Propanidid.

*E. Ether.

9. Progressive drop of blood pressure is developed in patient under general anaesthesia. Doctor administers to him the injection of adrenaline. Owing to this, ventricular fibrillation is developed in patient. Call general anaesthetic which is used for narcosis in this case.

A. Ketamine.

B. Nitrous oxide.

C. Oxytutirate sodium.

D. Thiopental sodium.

*E. Phthorotanum.

Hypnotic Drugs. Ethyl Alcohol

1. A female complains of insomnia after psycho-emotional stress. What drug has advantage for treatment of this female?

A. Barbital.

B. Phenobarbital.

C. Aethaminalum-natrium (pentobarbital).

D. Barbamil.

*E. Nitrazepam.

2. A patient complains of insomnia due to emotional disturbances. The doctor has prescribed him hypnotic drug with tranquilizer action. What drug has been prescribed to patient?

A. Bromisoval.

B. Phenobarbital.

C. Chloral hydrate.

D. Aethaminalum-natrium.

*E. Nitrazepam.

3. An 18-year-old patient complains of insomnia, which is manifested as difficulty in getting to sleep. As a result, on the next day the patient feels weakness, weariness, and has difficulty in training. The doctor has defined, that the insomnia is connected with neurosis. Make the rational choice of hypnotic drug.

A. Aethaminalum-natrium.

B. Bromisoval.

C. Chloral hydrate.

D. Phenobarbital.

*E. Nitrazepam.

4. A 17-year-old woman took big dose of phenobarbital for suicidal purpose. The urgent doctor made gastric lavage, introduced bemegride and sodium hydrocarbonate solution intravenously. What has the doctor introduced the sodium hydrocarbonate for?

A. For wakening effect.

B. For stimulation of breathing.

C. For normalization of blood pressure.

D. For inactivation of phenobarbital.

*E. For increase of kidney excretion of phenobarbital.

5. A 50-year-old female suffers from insomnia. She has used different hypnotic drugs (aethaminalum-natrium, phenobarbital, and barbamil) during 3 months. After withdrawal of drugs the female became irritable, aggressive, tremor of hands, and loss of appetite have appeared. What is the complication, which has developed in female called?

A. Functional cumulation.

B. Tachyphylaxis.

C. Sensibilization.

D. Tolerance.

*E. Physical and psychic dependence.

6. Prescribe a patient complaining of insomnia a modern soporific, which is an imidopyridinum derivative. It influences benzodiazepine receptors in the CNS, does not violate the structure of sleep, does not result in dependence, does not change the activity of liver enzymes. What is it?

A. Phenobarbital.

B. Chloral hydrate.

C. Nitrazepam.

D. Calcium chloride.

*E. Zolpidem.

7. The effective hypnotic drug which does not influence upon REM sleep is prescribed to patient with sleeping disorders. Choose this drug.

A. Aminazine.

B. Phenobarbital.

C. Oxybate sodium (natrii oxybutiras).

D. Dimedrol.

*E. Zopiclone.

8. A doctor has introduced intramuscularly caffeine to young patient in condition of alcohol intoxication. What is the base of expediency of such manipulation?

A. Summation of affects.

B. Synergism.

C. Potentiation.

D. Competitive antagonism.

*E. Physiological antagonism.

9. Desulfiram is widely used in medical practice to prevent alcoholism. It inhibits aldehyde dehydrogenase. Increased level of what metabolite causes aversion to alcohol?

A. Ethanol.

B. Methanol.

C. Propionic aldehyde.

D. Malonyl aldehyde.

*E. Acetaldehyde.

^ Antiepileptic and Antiparkinsonic Drugs

1. A doctor discusses with colleagues the use of new antiepileptic drug – sodium valproate. What is the mechanism of action of this drug?

A. Inhibition of MAO.

B. Stimulation of GABA-transferase activity.

C. Inhibition of Ca2+-dependent ATP-ase activity.

D. Stimulation of Ca2+-dependent ATP-ase activity.

*E. Inhibition of GABA-transferase activity.

2. A patient complains of muscles rigidity, constant tremor of hands, and slowing down of motions. In the result of examination the doctor determined the diagnosis of Parkinson’s disease. Choose the rational drug for treatment of this patient.

A. Ethosuximide.

B. Dipheninum (phenytoin).

C. Phenobarbital.

D. Sibazonum (diazepam).

*E. Levodopa.

3. A 58-year-old male complains of Parkinson’s disease. Patient also suffers from glaucoma. What drug should be prescribed to the patient?

A. Cyclodolum (trihexyphenidyl).

B. Phenobarbital.

C. Dipheninum.

D. Ethosuximide.

*E. Levodopa.

4. Tremor and disturbances of coordination are observed in 68-year-old male. His diagnosis is Parkinson’s disease. What drug should be prescribed to the patient?

A. Ethosuximide.

B. Phenobarbital.

C. Dipheninum (phenytoin).

D. Finlepsinum.

*E. Levodopa.

5. Levodopa was prescribed to 70-year-old male, who suffers from Parkinson’s disease. In a week the condition of patient significantly improved. What is the mechanism of levodopa action?

A. Activation of encephalinergic system.

B. Suppression of cholinergic system.

C. Braking of histaminergic system.

D. Suppression of serotoninergic system.

*E. Activation of dopaminergic system.

6. Convulsions with the loss of consciousness appear periodically in 5-year-old child. The doctor has diagnosed epilepsy (grand mal). What drug should be prescribed in this case?

A. Amizylum.

B. Cyclodolum (trihexyphenidyl).

C. Ethosuximide.

D. Levodopa.

*E. Phenobarbital.

7. A patient, who suffers from grand mal with loss of consciousness, amnesia, and spontaneous outflow of urine, was treated in neurological unit. What drug should be prescribed to him?

A. Levodopa.

B. Ethosuximide.

C. Clonazepam.

D. Trimethinum.

*E. Phenobarbital.

8. A patient suffers from posttraumatic epilepsy (grand mal). What drug should be prescribed to the patient?

A. Midantanum (amantadine).

B. Cyclodolum.

C. Levodopa.

D. Teturamum (disulfiram).

*E. Phenobarbital.

9. A patient with epilepsy accepted phenobarbital in daily dose 0.4 g for a long time. Recently the attacks of epilepsy became more frequent. What is the reason of patient’s condition deterioration?

A. Inhibition of glycolysis.

B. Inhibition of microsomal hepatic enzymes.

C. Activation of lipolysis.

D. Activation of gluconeogenesis.

*E. Induction of microsomal hepatic enzymes.

10. A 42-year-old man who has been injured in a car accident is brought into the emergency room. His blood alcohol level on admission is 250 mg/dL. Hospital records show a prior hospitalization for alcohol related seizures. His wife confirms that he has been drinking heavily for 3 weeks. What treatment should be provided to the patient if he goes into withdrawal?

A. Phenitoin.

B. Pentobarbital.

C. None.

D. Phenobarbital.

*E. Diazepam.

11. A 58-year-old man came to a doctor with complains of trembling, akinesia, muscular rigidity. The doctor has diagnosed Parkinson’s disease. This patient also suffers from glaucoma. What drug is it necessary to prescribe?

A. Methacinium.

B. Cyclodolum.

C. Atropine sulfate.

D. Scopolamine hydrobromide.

*E. Levodopa.

12. A 70-year-old man with Parkinson’s disease has been appointed a drug levodopa. In a week the condition of the patient has considerably improved. What is the mechanism of this drug action?

A. Activation of opiate receptors.

B. Inhibition of cholinergic receptors.

C. Inhibition of histaminic receptors.

D. Inhibition of serotoninergic receptors.

*E. Activation of dopamine receptors.

13. A 5-year-old child periodically experiences convulsive attacks with loss of consciousness. A doctor diagnosed epilepsy. What drug is recommended to this child?

A. Amizylum.

B. Cyclodolum.

C. Ethosuximide.

D. Levodopa.

*E. Phenobarbital.

14. A drug, derivative of dipropylacetic acid, which depresses GABA-transferase, raising the content of GABA in the tissues of the brain, reduces the excitability and readiness for convulsions of motor zones of the brain, has been prescribed to a patient with epilepsy. It is applied under all forms of epilepsy. What is this drug?

A. Sodium bromide.

B. Diazepam.

C. Tinctura Valerianae.

D. Reserpine.

*E. Sodium valproate.

15. The significant improvement of motor performance is observed in patient with Parkinson’s disease after prolonged using of drug which is transformed into dopamine in the result of decarboxilation. What drug does the patient use?

A. Aminazine.

B. Naloxone.

C. Celecoxib.

D. Droperidol.

*E. Levodopa.

16. The prescribing of levodopa to 60-year-old patient with Parkinson’s disease rapidly improves him condition. What is the mechanism of drug action?

A. Stimulation of M-cholinoceptors.

B. Blockade of M-cholinoceptors.

C. Stimulation of dopaminergic receptors.

D. Anticholinesterase action.

*E. Activation of dopamine synthesis.

17. A patient has appealed to doctor with complaints of muscles rigidity, tremor, and restraint of movements. In result of examination the doctor made diagnosis of Parkinson’s disease. Make correct choice of drug.

A. Ethosuximide.

B. Dipheninum.

C. Phenobarbital.

D. Sibazonum.

*E. Levodopa.

18. A patient suffers from repeating attacks of epileptic convulsions with loss of consciousness. What group of drug is used first of all for seizures elimination in this case?

A. Sedative drugs.

B. Neuroleptics.

C. Miorelaxants.

D. Analeptics.

*E. Tranquilizers.

19. A patient consulted a physician about muscle rigidity, constrained movements, permanent arm tremor. The patient was diagnosed with Parkinson’s disease. What drug should be administered?

A. Ethosuximide.

B. Diazepam.

C. Phenytoin.

D. Phenobarbital.

*E. Levodopa.

^ Opioid Analgesics

1. A patient with signs of poisoning by morphine was delivered to emergency department. What drug should be used in this case for gastric lavage?

A. Boric acid.

B. Sodium hydrocarbonate.

C. Nitrofural (furacilinum).

D. Solution of sodium chloride.

*E. Potassium permanganate.

2. A patient in postoperative period received promedolum (trimeperidine). In the result of drug interruption the serious psychical and physical disturbances developed in patient. What is this complication called?

A. Tolerance.

B. Idiosyncrasy.

C. Tachyphylaxis.

D. Phenomenon of feedback.

*E. Abstinence.
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