3395 Krok-1 Pharmacology icon

3395 Krok-1 Pharmacology




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3. An unconsciousness patient was delivered to the hospital. The skin is cold, pupils are narrow, the breathing is complicated and periodic, blood pressure is low, and the bladder is overflowed. What group of drug is the reason of this poisoning?

A. Neuroleptics.

B. Tranquilizers.

C. Nonopioid analgesics.

D. M-cholinoblockers.

*E. Opioid analgesics.

4. Acute spastic pain has developed in patient with urolithiasis. For prevention of pain shock the doctor has introduced to patient atropine with opioid analgesic, which has not spasmogenic action. Call this opioid analgesic.

A. Ethylmorphine hydrochloride.

B. Tramadol.

C. Pyritramide.

D. Morphine hydrochloride.

*E. Promedolum (trimeperidine).

5. A doctor prescribed promedolum to patient with nonresectable tumor of stomach. After some time the patient has noted the decrease of analgesic action and duration of drug action. What is the reason of this phenomenon?

A. Decrease of drug reabsorption in kidneys.

B. Tachyphylaxis.

C. Psychical dependence.

D. Cumulation of promedolum.

*E. Tolerance.

6. A patient in the unconscious state was admitted to the emergency room. Skin is cold, pupils are delayed, breathing is heavy, with cycles of the Cheyne-Stokes type, blood pressure is decreased, urinary bladder is overloaded. Poisoning with what substance is the most likely?

A. M-cholinergic agonists.

B. Nonnarcotic analgesics.

C. Sedatives.

D. M-cholinergic antagonists.

*E. Narcotic analgesics.

7. A 70-year-old man, who suffered from chronic bronchitis, was prescribed drug for the cough – codeine. What is the mechanism of anticoughing effect of this drug?

A. Competitive action.

B. Reflex.

C. Local effect.

D. Peripheral effect.

*E. Central effect.

8. A patient was prescribed narcotic analgesic, which is derivative of cyclohehanol, agonist-antagonist of opiate receptors, a little weaker than morphine. It does not influence the digestive tract, has some analgesic action, is characteristic of nonnarcotic analgesics; it is not recommended for children under 14. What is this drug?

A. Omnopon.

B. Promedolum.

C. Morphine hydrochloride.

D. Codeine phosphate.

*E. Tramadol.

9. In 2–3 hours after the parenteral introduction of a drug a patient became comatose. Cheyne-Stokes respiration was observed, pupils became abruptly miotic, knee reflex was kept. What drug could lead to the poisoning?

A. Phenobarbital.

B. Diazepam.

C. Aminazine.

D. Ethyl alcohol.

*E. Morphine.

10. An unconscious patient has been taken to a hospital. His skin is cold, pupils are miotic, breathing is complicated (Cheyne-Stokes type), arterial pressure is low, the urinary bladder is overfilled. The diagnosis is poisoning with morphine. What drug is it necessary to give as an antidote?

A. Sodium thiosulfate.

B. Bemegride.

C. Cytitonum.

D. Unithiole.

*E. Naloxone.

11. A 35-year-old parturient woman has a pain syndrome connected with the delay of the first labor stage. What drug is necessary to be used for relieving the pain?

A. Paracetamol.

B. Analginum.

C. Morphine.

D. Codeine.

*E. Promedolum.

12. An emergency team has taken to a reception ward a patient demonstrating drowsiness, cyanosis, and infrequent cogged-wheel breathing, sharply miotic pupils. Knee reflexes are kept. The traces of injections are revealed on his arms. What drug causes poisoning characterized by the above-mentioned symptom?

A. Aminazine.

B. Atropine.

C. Proserinum.

D. Phenobarbital.

*E. Morphine.

13. A 30-year-old patient after a traffic accident was delivered to a hospital with a hip bones fracture. The patient has low arterial pressure, weak pulse, and increased pain reaction to the least touch in the place of damage. What is necessary to use to prevent the traumatic shock of this patient?

A. Papaverine.

B. Paracetamol.

C. Pentazocine.

D. Analginum.

*E. Morphine.

14. A 25-year-old woman is hospitalized with signs of acute poisoning with morphine. What antidote is necessary to be given to the patient?

A. Aethymizole.

B. Unithiole.

C. Atropine.

D. Lobeline.

*E. Naloxone.

15. A patient with poisoning with morphine has been delivered to a hospital. It is known that in case of acute poisoning with morphine a specific antagonist naloxone is used. What factor provides the development of antagonistic action?

A. Decrease of sensitivity of the organism to morphine.

B. Direct excitation of respiratory centre.

C. Reflex excitation of respiratory centre.

D. Sharp acceleration of morphine metabolism.

*E. Competition for binding with opiate receptors.

16. Morphine hydrochloride solution has been introduced subcutaneously to a patient with traumatic shock to provide analgesia. What is the mechanism of analgesic effect of this drug?

A. Inhibition of pain mediators formation on peripheral tissues.

B. Blockade of peripheral sensitive receptors.

C. Change of pain emotional colouring.

D. Abnormality of afferent nerves impulses conduction.

*E. Interaction with opiate receptors.

17. A patient suffering from urolithiasis is hospitalized because of an attack of renal colic. What emergency drug is to be prescribed in this case?

A. Contrycal.

B. Analginum.

C. Paracetamol.

D. Furosemide.

*E. Promedolum.

18. For anaesthesia of labor a doctor prescribed an analgesic. What analgesic is the most expedient to use in this case?

A. Paracetamol.

B. Analginum.

C. Morphine.

D. Phentanyl.

*E. Promedolum.

19. A 15-year-old boy with manifestations of acute poisoning with narcotic analgesics was prescribed a specific antagonist of morphine hydrochloride. What is this drug?

A. Bemegride.

B. Tetacinum-calcium.

C. Pentazocine.

D. Unithiole.

*E. Naloxone.

20. Prescribe to patient a drug – a synthetic substitute of morphine, which has a sedative effect, does not spasm muscles and sphincters of the digestive tract, slightly influences the centre of respiration, and reduces the tone of uterus neck.

A. Analginum.

B. Omnopon.

C. Phentanyl.

D. Paracetamol.

*E. Promedolum.

21. An unconscious patient is hospitalized to a resuscitation unit with symptoms of acute morphine poisoning: hypothermia, Cheyne-Stokes respiration, hypotension, bradycardia, acute miosis. Which of the listed drugs will be the most effective in this case?

A. Caffeine sodium benzoate.

B. Cordiaminum.

C. Camphora.

D. Aethymizole.

*E. Naloxone.

22. A 26-year-old patient in coma is brought in intensive care unit. The temperature is 35 0C. The skin is cold. Mucous membranes are cyanotic. Sharply miotic pupils are observed. Breath is oppressed, as Chejn-Stoks type. What drug is the cause of poisoning?

A. Anaprilinum.

B. Proserinum.

C. Adrenaline.

D. Atropine.

*E. Morphine.

23. A 60-year-old patient suffers from incurable cancer of lung with multiple metastases. Choose the drug for pain relief in this patient.

A. Paracetamol.

B. Diclofenac sodium.

C. Analginum.

D. Fentanyl.

*E. Morphine.

24. A 20-year-old patient is delivered to urgent unit with poisoning with opium. What the most effective drug should be administered to him?

A. Potassium permanganate.

B. Atropine.

C. Aethymizole.

D. Active carbon.

*E. Naloxone.

25. A victim with hip and ribs fractures is delivered to emergency room after road accident. What drug should be administered to patient for prevention of pain shock?

A. Tramadol.

B. Analginum.

C. Nitric oxide.

D. Diazepam.

*E. Morphine.

26. A patient with myocardial infarction is delivered to resuscitation unit. What drug should be administered to patient for prevention of painful shock?

A. Naloxone.

B. Analginum.

C. Paracetamol.

D. Celecoxib.

*E. Morphine.

27. A parturient woman is delivered to obstetrics department. The doctor administered to woman opioid analgesic for pain relief. Indicate this drug.

A. Diclophenac sodium.

B. Acetylsalicylic acid.

C. Analginum.

D. Celecoxib.

*E. Promedolum.

28. A patient with serious trauma is delivered to emergency room. For prevention of painful shock, a doctor administered to him opioid analgesic. Indicate this drug.

A. Celecoxib.

B. Paracetamol.

C. Piroxicam.

D. Acetylsalicylic acid.

*E. Morphine.

29. Antagonist of opioid analgesics was administered to patient with significant signs of opioid intoxication. Indicate this drug.

A. Fentanyl.

B. Morphine.

C. Promedolum.

D. Omnopon.

*E. Naloxone.

30. A patient with morphinism is delivered to narcological unit. In the result of examination, a doctor indicated the decreasing of morphine action. Indicate the name of phenomenon of weakening of drug action in the result of repeated drug administration.

A. Summation.

B. Material cumulation.

C. Functional cumulation.

D. Antagonism.

*E. Tolerance (accustoming).


^ Nonsteroid Anti-inflammatory Drugs

(Nonopioid Analgesics)


1. After the usage of acetylsalicylic acid a patient developed epigastric pain because of exacerbation of his ulcer. What are the principles of this medication ulcerogenity?

A. Stimulation of pepsin secretion.

B. Spasm of vessels.

C. Immunodepressive effect.

D. Cholagogic effect.

*E. Antiprostaglandinic effect.

2. Aspirin has anti-inflammatory effect due to inhibition of the cyclooxygenase activity. Level of what biological active compounds will decrease?

A. Biogenic amines.

B. Catecholamines.

C. Leucotrienes.

D. Iodinethyronyns.

*E. Prostaglandins.

3. Signs of gastropathy develop in the patient with rheumatoid arthritis who was treated with indomethacin. What activity of the drug does cause this complication?

A. Antihistamine.

B. Antiserotonin.

C. Local irritating.

D. Antikinine.

*E. Anticyclooxygenase.

4. A child with hyperthermia has been prescribed a drug, which is an active metabolite of phenacetine, has strong antipyretic action. It can be inactivated by conjugation with glutathione. In toxic doses it can damage liver cells. Antidotes in case of poisoning are acetylcysteine and methionine. What is this drug?

A. Phenobarbital.

B. Atropine sulfate.

C. Phosphacolum.

D. Caffeine sodium benzoate.

*E. Paracetamol.

5. A patient with a headache was prescribed a drug – a derivative of pyrazolone, which has analgesic and antipyretic action. It has negative influence on haemopoiesis in case of long application. It is forbidden as monotherapy in the countries of the Schengen Agreement. What is this drug?

A. Aethymizole.

B. Paracetamol.

C. Pyracetam.

D. Aminazine.

*E. Analginum.

6. A patient with arthritis of knee joint also suffers from ulcer disease of stomach. What drug is preferable to pain relief in knee joint for this patient?

A. Tramal.

B. Analginum.

C. Aspirin.

D. Promedolum.

*E. Celecoxib.

7. A 25-year-old patient used for relief of toothache the
nonopioid analgesic from group of aniline derivatives. What is this drug?

A. Ibuprofen.

B. Acetylsalicylic acid.

C. Analginum.

D. Butadione.

*E. Paracetamol.

8. The prolonged use of nonsteroid anti-inflammatory drug in patient with arthritis and varicose phlebectasia has caused the thrombosis of skin veins. Indicate the drug which can cause this complication.

A. Ibuprofen.

B. Indomethacin.

C. Aspirin.

D. Butadione.

*E. Celecoxib.

9. A patient with fever was delivered to infectious unit. The nonopioid analgesic – derivative of salicylic acid is prescribed to patient. Indicate this drug.

A. Diclophenac sodium.

B. Analginum.

C. Ibuprofen.

D. Paracetamol.

*E. Acetylsalicylic acid.

10. A patient with acute respiratory viruses disease and hyperthermia is delivered to infectious unit. What drug should be prescribed for decrease of temperature?

A. Retabolil.

B. Ambroxol.

C. Salbutamol.

D. Adrenaline.

*E. Paracetamol.

11. For decreasing of gastric mucosa damage possibility, the
nonsteroid anti-inflammatory agent – selective inhibitor of COX-2 is prescribed to patient with rheumatoid arthritis. Indicate this drug.

A. Ibuprofen.

B. Analginum.

C. Acetylsalicylic acid.

D. Butadione.

*E. Celecoxib.

10. Indicate a drug, the therapeutic effects of which are the result of prostaglandins synthesis inhibition.

A. Morphine.

B. Fentanyl.

C. Carbamazepine.

D. Lithium salts.

*E. Acetylsalicylic acid.

11. A female consulted a doctor about pain and limited movements in the knee qoints. Which of the following nonsteroid anti-inflammatory drugs should be administered taking into consideration that the patient has a history of chronic gastroduodenitis?

A. Acetylsalicilic acid.

B. Promedolum.

C. Butadione.

D. Diclofenac sodium.

*E. Celecoxib.


^ Antipsychotics, Antidepressants, and Lithium Salts


1. A patient was treated medically for psychosis for 2 weeks. Patient’s condition improved but rigidity, tremor, and hypokinesia developed. Which of the drugs can cause such complications?

A. Sydnocarb.

B. Imipramine.

C. Chlordiazepoxide.

D. Dipheninum.

*E. Aminazine.

2. To eliminate delirium and hallucinations of a patient with schizophrenia a doctor used aminazine. What is the mechanism of antipsychotic action of the drug?

A. Blockade of the inverse neuronal capture of catecholamines.

B. Stimulation of adrenergic and dopaminergic processes in the CNS.

C. Stimulation of cholinergic processes in the CNS.

D. Blockade of cholinergic processes in the CNS.

*E. Blockade of adrenergic and dopaminergic processes in the CNS.

3. A patient with manic-depressive psychosis and manifestations of depression complains of anxiety and fear. What antidepressant with accompanying psychosedative effect is it necessary to prescribe?

A. Phenazepam.

B. Imizinum.

C. Sydnocarbum.

D. Nialamide.

*E. Amitriptyline.

4. A drug shows a strong, fast, but not long-term neuroleptic action. It potentiates the action of analgesic, soporific agents, alcohol. It has antishock and antiemetic action. It belongs to buthyrophenone derivatives. What is this drug?

A. Sulpiride.

B. Triftazine.

C. Aminazine.

D. Clozapine (azaleprtinum).

*E. Droperidol.

5. A patient developed symptoms of medicinal parkinsonism after psychosis treatment in a mental hospital. What drug had been used for his treatment?

A. Nialamide.

B. Mezapam.

C. Sodium bromide.

D. Lithium carbonate.

*E. Aminazine.

6. Acute heart attack is accompanied by retrosternal pain. Ineffectiveness of preliminary taken drugs has made the doctor to perform neurolepanalgesia. What neuroleptic is used for this type of anaesthesia?

A. Aminazine.

B. Meterazin.

C. Haloperidol.

D. Reserpine.

*E. Droperidol.

7. A 38-year-old man suffers from schizophrenia. He has come to a doctor with complaints of disorder of coordination and movements, tremor in his hands, drowsiness. The patient has been taking psychotropic drugs for a long period of time. What group of drugs can lead to such complex of symptoms?

A. Adaptogens.

B. Analgesics.

C. Antidepressants.

D. Psychomotor stimulants.

*E. Neuroleptics.

8. A patient with maniac-depressive psychosis demonstrates inhibition of mental and impellent activity, agitation, depression. What drug is it necessary to prescribe in order to relieve pathological depression?

A. Triftazinum.

B. Sydnocarbum.

C. Caffeine sodium benzoate.

D. Pyracetam.

*E. Amitriptyline.

9. A man is kept under dispensary observation in a psychoneurologic clinic because of chronic alcoholism. Alcohol abuse led to acute psychosis. What drug can be expediently used?

A. Adrenaline.

B. Atropine.

C. Pentamine.

D. Hygronium.

*E. Aminazine.

10. What neuroleptic is characterized by the following properties: phenothiazine derivative, blocks postsynaptic dopamine and adrenergic receptors in the CNS, provides a sedative effect on the CNS, prolonged application can induce extrapyramidal abnormalities and neuroleptic syndrome?

A. Haloperidol.

B. Diazepam.

C. Triftazinum.

D. Droperidol.

*E. Aminazine.

11. A woman tried to commit suicide. A psychiatrist detected a condition of endogenous depression of this patient. What medication is expedient to prescribe to the patient for the course of treatment?

A. Caffeine sodium benzoate.

B. Sydnocarbum.

C. Aethymizole.

D. Pyracetam.

*E. Amitriptyline.

12. A patient with schizophrenia takes aminazine. Which of the listed pharmacodynamic effects is the basic one in this case?

A. Hypotensive.

B. Antiemetic.

C. Hypothermic.

D. Muscle relaxing.

*E. Antipsychotic.

13. An ambulance has delivered to a hospital a patient, who tried to commit suicide in the condition of severe depression. The diagnosis is depressive psychosis. The drug of which pharmacological group is it necessary to prescribe to the patient?

A. Lithium salts.

B. Sedatives.

C. Neuroleptics.

D. Tranquilizers.

*E. Antidepressants.

14. A patient suffering from Parkinson’s disease needs additional treatment concerning accompanied pathology. Indicate the group of drugs which can cause aggravation of Parkinson’s disease in this patient?

A. Antidepressants.

B. Tranquilizers.

C. Hypnotics.

D. M-cholinoblockers.

*E. Antipsychotic drugs (neuroleptics).

15. The first aid brigade has delivered to a hospital the patient with obvious psychomotor disturbances. What drug should be administered to the patient?

A. Bisacodyl.

B. Piracetam.

C. Rifampicin.

D. Heparin.

*E. Aminazine.

16. A surgery patient needs neuroleptanaesthesia. What drug is most commonly used for neuroleptanaesthesia together with fentanyl?

A. Fraxiparine.

B. Cholosasum.

C. Salbutamol.

D. Pilocarpine.

*E. Droperidol.

17. Pharmacological effects of antidepressants are based upon blocking (inhibiting) the enzyme that acts as a catalyst for the breakdown of biogenic amines noradrenaline and serotonin in the mitochondria of cephalic neurons. What enzyme takes part in this pro-cess?

A. Decarboxylase.

B. Lyase.

C. Transaminase.

D. Peptidase.

*E. Monoamine oxidase.


^ Tranquilizers and Sedative Drugs


1. A patient has taken the mixture prescribed by neuropathologist for neurasthenia for 2 weeks. Patient felt better but developed coryza, conjunctivitis, rash, inertia, decrease of memory. Bromizm was diagnosed. What should be prescribed to decrease symptoms?

A. Diazepam.

B. Asparcam.

C. 5% glucose solution.

D. Polyglucin.

*E. Sodium chloride.
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