Lugansk state medical university chair of clinical pharmacology and pharmacotherapy icon

Lugansk state medical university chair of clinical pharmacology and pharmacotherapy




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НазваLugansk state medical university chair of clinical pharmacology and pharmacotherapy
Дата03.08.2012
Розмір123.69 Kb.
ТипДокументи
1. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/KTP-UA.doc 5ъ.doc
2. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/KTP-UA.doc.doc
3. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/KTP-UA.doc4 ъєЁё.doc
4. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/MVOPR_UA.doc.doc
5. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/PROGRAM.doc.doc
6. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/VOPR_RU.doc.doc
7. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciafarmaciya/VOPR_UAdoc.doc
8. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmaciainterny/KTP-UA.doc
9. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki4,5/KTP_UA.doc.doc
10. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki4,5/PROGRAM.doc.doc
11. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki4,5/VOPR_UA.doc.doc
12. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki5,5/KTP_UAdoc.doc
13. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki5,5/MVOPR_UA.doc.doc
14. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki5,5/PPROGRAM.doc.doc
15. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiazaohniki5,5/VOPR_UA.doc.doc
16. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyaBAKALAVRY/KTP_UA.doc.doc
17. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyaBAKALAVRY/PROGRAM.doc.doc
18. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyaBAKALAVRY/VOPR_UA.doc.doc
19. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyaklinordinatory/KT_UA.doc.doc
20. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyaklinordinatory/MVOPR_UA.doc.doc
21. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/KTP_EN.doc.doc
22. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/KTP_UA.doc.doc
23. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/MVOPR_EN.doc.doc
24. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/MVOPR_RU.doc.doc
25. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/MVOPR_UA.doc.doc
26. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/OTHER1_EN.doc.doc
27. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/OTHER_EN.doc.doc
28. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/OTHER_UA.doc.doc
29. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyalechebniki/THE PLAN OF THE WRITING.doc
30. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyastomatologiya/KTP_UA.doc.doc
31. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyastomatologiya/PROGRAM.doc.doc
32. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_Clinfarmakologiyastomatologiya/ьхЄюф фыя тшъырф 5 ъєЁё ъышэфрЁьръ ёЄюьрЄ.doc
33. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyastoxikologityBAKALAVRY/KTP-UA.doc.doc
34. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyastoxikologityBAKALAVRY/PROGRAM.doc.doc
35. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyastoxikologityBAKALAVRY/VOPR_UAdoc.doc
36. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyastoxikologityZAOCHNIKI/FORM137.doc.docx
37. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_ClinfarmakologiyastoxikologityZAOCHNIKI/VOPR_UA.doc.doc
38. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_PROPEDEVIKAVNUTRISHNIHHVOROB/KTP_UA.doc
39. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_PROPEDEVIKAVNUTRISHNIHHVOROB/MMVOPR_UA.doc.doc
40. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_PROPEDEVIKAVNUTRISHNIHHVOROB/OTHER_UA.doc.doc
41. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_PROPEDEVIKAVNUTRISHNIHHVOROB/PROGRAM.doc.doc
42. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_VNUTRISHNIHHVOROBY/KTP_UA.doc.doc
43. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_VNUTRISHNIHHVOROBY/MVOPR_RU.doc.doc
44. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_VNUTRISHNIHHVOROBY/MVOPR_UA.doc.doc
45. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_VNUTRISHNIHHVOROBY/PROGRAM.doc.doc
46. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmacoterapiafarmacia/KTP-UA.doc.doc
47. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmacoterapiafarmacia/PROGRAM.doc.doc
48. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmacoterapiafarmacia/VOPR_RU.doc.doc
49. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmacoterapiafarmacia/VOPR_UA.doc.doc
50. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmakoterapiazaohniki4,5/KTP-UA.doc.doc
51. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmakoterapiazaohniki4,5/PROGRAM.doc.doc
52. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmakoterapiazaohniki4,5/VOPR_UA.doc.doc
53. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmopikafarmacia/KTP-UA.doc.doc
54. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmopikafarmacia/KTP-UAspecialazaciya.doc.doc
55. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_farmopikafarmacia/PROGRAM.doc.doc
56. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_kurspovyborufarmaciya/KTP-UA.doc.doc
57. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikafarmaciya/KTP-UA.doc.doc
58. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikafarmaciya/PROGRAM.doc.doc
59. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikafarmaciya/ъры.Єхь.яы яю ырс.фшруэ..doc
60. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikazaohnik5,5/TIME-UA.doc.doc
61. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikazaohnik5,5/яшЄрээя Єр эртшчъш фю ьюфєыьэюую ъюэЄЁюыю ч ПДД.doc
62. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_laboratornayadiagnostikazaohniki4,5/KTP-UA.doc.doc
63. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershadolikarnyanadopomogafarmacia/KTP-UA.doc.doc
64. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershadolikarnyanadopomogafarmacia/MVORP_UA.doc.doc
65. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershadolikarnyanadopomogafarmacia/PROGRAM.doc.doc
66. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershadolikarnyanadopomogafarmacia/МЕТОДИЧКИ ДЛЯ СТУД 2 КУРС ПДД.doc
67. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershadolikarnyanadopomogazaohniki4,5/KTP_UA.doc.doc
68. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershdolikarnyanadopomoga/KTR_RU.doc.doc
69. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershdolikarnyanadopomoga/MVOPR_UA.DOC.doc
70. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershdolikarnyanadopomoga/PROGRAM.doc.doc
71. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_pershdolikarnyanadopomoga/VOPR_UA.DOC.doc
72. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_specializaciafarmaciya/KTP-UA.doc.doc
73. /farm_kafedra_klinichnoi_farmakologii_ta_farmakoterapii/КрфхфЁр ъыіэічэюї фрЁьръюыюуії Єр фрЁьръюЄхЁряії/Clinfarmakologiya_specializaciafarmaciya/MVOPR_UA.doc.doc
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LUGANSK STATE MEDICAL UNIVERSITY

CHAIR OF CLINICAL PHARMACOLOGY AND PHARMACOTHERAPY


METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASSES BY CLINICAL PHARMACOLOGY


Medical faculty, 5 course, specialties: „ medical business” and "pediatrics"


The composer: Belousova I.P.

The report № 20 from «18» June 2009, is confirmed on chair meeting,


Head of the chair, doctor of medical sciences,

professor Savchenkova L.V.


Lugansk, 2009


METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASS № 1


Themes:

  1. Object, tasks of clinical pharmacology. Clinical pharmacodynamic and pharmakokinetic of medical preparations. Clinical and pharmacological description of antihypertensive and hypertensive preparations |.

  2. Clinical and pharmacological description of diuretics |.


Duration of practical classes: 6 hours


Actuality of theme «Object, tasks of clinical pharmacology. Clinical pharmacodynamic and pharmakokinetic of medical preparations. Clinical and pharmacological description of antihypertensive and hypertensive preparations |»: During the last decade the requirements to|by| the test and application of new pharmacological preparations increased. The necessity of knowledges of mechanisms of action|act|, pharmacodynamical and a pharmakokinetical| features of medical preparations, reasons of appearance of undesirable effects and also providing of effective and safe application of drugs including in child's practice, by nursing women | and pregnant women, at old person appeared at the doctors.

Hypertensive illness in a present tense is|appears| the reason|cause| of grave|difficult| conditions|figures,states,camps,mills| and high lethality of population of the developed countries. So, a death rate from this disease makes|folds| 50% cases|accidents| of death rate from the diseases of the cardiovascular system|. That is why|that is why| the study of using|purpose| of rational medicinal treatment taking into account a pharmacodynamics, pharmakokinetics, interaction, undesirable effects of drugs at these diseases is|appears| very|highly| actual.


At the study of theme it is necessary to integrate with the following departments|pulpits|:

  • normal anatomy;

  • normal and pathology physiology;

  • by the clinical departments|pulpits| of therapeutic and surgical type|profile|;

  • department|pulpit| of children' illnesses.


Purpose general|common|: To learn the basic|main| sections|divisions| of clinical pharmacology: pharmakokinetic, pharmacodynamic, undesirable effects of medical preparations, interactions. To indicates|indicates| the basic|main| tasks of clinical pharmacology, principles of estimation of efficiency and safety of medical preparations.

To study|studies,learns| clinical pharmacology and rational pharmacotherapy |of hypertonic and hypotonic diseases.

Concrete aims: To master concepts|notions|, stages, conformities to the law of pharmakokinetic, pharmacodynamic, interactions of preparations, sides effects and methods of their correction. Features of pharmakokinetic at children|kids| and old persons|personalities,individuals|, at pregnant and nursing women|wives|.

To learn clinical and pharmacological description of antihypertensive and hypertensive preparations.

To know:

  • a concept|notion| of «pharmacodynamic», basic|main| stages of pharmakokinetic, types of co-operation of drugs;

  • mechanism of action|act|, pharmacodynamics, pharmakokinetics of and
    antihypertensive preparations;

  • indications and contrindications to application |purpose|, undesirable effects
    of afore-mentioned preparations, features of action|act| of drugs, in child's
    age and in the organism of old persons|personalities,individuals|, at pregnant and nursing women, features of their application.

To be able:

- to conduct the adequate choice and to appoint|sets| the most effectiveness and safeness
drugs at hypertensive disease, ischemic disease, collapse,
hypotonia and other states|figures,camps,mills|.

  • to analyze the results of pharmakokinetic and pharmacodynamic
    of drugs.

  • to conduct the choice of drugs. To take into account the features of choice at children|kids| taking into account efficiency and safety of application of drugs.

  • to forecast and discover|exposes,shows,reveals,displays| on early stages indirect actions|acts| of drugs,
    to conduct their correction.


Theoretical questions to|by| the theme:

1. The purpose and tasks of clinical pharmacology

1.1. To realize the purpose and problems{tasks} of clinical pharmacology

    1. To determine the deontological problems of clinical pharmacology

2. Principles of a pharmacokinetics, factors which influence a pharmacokinetics.

2.1. The basic parameters of a pharmacokinetics

2.2. Ways of introduction of medical agents

    1. Mechanisms of distribution of medical agents in an organism

2.4. Absorption of medical agents from a gastrointestinal tract

2.5. Features of distribution of medical agents in an organism, linkages with fibers of plasma

    1. Biotransformation of a medicine

    2. Elimination.

2.8. A quantitative estimation of elimination medical agents

2.9. Methods of an estimation of absorption of medical agents and their biological availability

2.10 Pharmacokinetics at reusable introduction of medical agents.

3. Principles of pharmacodynamic

3.1. The general{common} representation about the mechanism of action. Specificity and selectivity

    1. Mutual relations between a dose and effect.

    2. Interrelation between a pharmacokinetics and a pharmacodynamic.

3.4. Century aspects of a pharmacodynamic.

3.5. Dependence of effect on gravity of disease and a condition of the basic functional systems of an organism.

4. Principles of interaction of medical products.

4.1. Character of interaction: pharmaceutical, pharmacokinetic, pharmacodynamic, physiological

4.2. The clinical characteristic of displays of probable interactions - additive, sensitive, opposing, etc.

4.3. Dependence of interaction on character and gravity of a lesion of internal organs, a functional condition of regulative systems, emptiness of a mouth, age of the patient.

4.4. Main principles of a choice of a rational combination of medical agents with the purpose of rising of efficiency and safety of medical therapy at diseases of emptiness of a mouth at the concrete patient.

5. The Side effect of medical agents.

5.1. Classification of side effects

5.2. Main principles of therapy of side effects of medical agents

6. Influence of medical agents on a fetus and the baby

6.1. Features of a pharmacokinetics of medical agents at a fetus, the baby, children of different age.

6.2. Penetrations of medical agents through a placenta. Concentration of medical agents in maternal milk.

6.3. Teratogenous and embriotoxic ability.

6.4. Pharmacogenetic aspects in pediatrics

  1. Basic|main| elements of pathogeny of hypertensive illness and ways of influencing on them of drugs.

  2. Classification of drugs which|what| diminish tone of vessels.

  3. Mechanism of action|act|, pharmacodynamics, pharmakokinetics, clinical application.

  4. Basic elements of a pathogenesis of an idiopathic hypertension and way of influence on them of medical agents.

  5. Classification of medical agents which reduce a tonus of vessels.

  6. Mechanism of action, pharmacodynamics, pharmacokinetics, clinical application of antihypertensives which influence subthalamic departments of the central nervous system.

  7. α-adrenoblocers: the comparative characteristic, pharmacodynamics, a pharmakokinetics.

  8. β- adrenoblocers: pharmacodynamics, a pharmakokinetics, clinical application.

  9. Myotropic agents: the mechanism of action, clinical application.


Actuality of theme «Clinical and pharmacological description of diuretics |»: diuretics are widely used in clinical practice for treatment of numerous diseases of cardiovascular, |urinal and endocrine systems. Some|certain| diuretics are|appears| inalienable part of reanimations measures|steps|. Therefore|here|, there is a necessity in the careful study of pharmacodynamic, pharmakokinetic, interaction, undesirable effects of these drugs.

Purpose general|common|: To learn|studies,learns| clinical pharmacology of diuretics.

Concrete aims: To learn clinical and pharmacological description of diuretics from different|diverse| groups.

To know:

  • mechanism of action|act|, pharmacodynamic, diuretic preparations of different|diverse| groups;

  • indications and contrindications to application |purpose|, undesirable effects
    of afore-mentioned preparations, features of action|act| of the drugs, in child's
    age and in the organism of old people, features of their application.

To be able:

- to conduct the adequate choice and to appoint|sets| the most effectiveness and safeness
diuretic at cardiac|hearty,kind| insufficiency, hypertonia, glaucoma, at kidney and hepatic insufficiency;

  • to analyze the parameters of pharmakokinetic and pharmacodynamic
    of drugs;

  • to conduct the choice of drugs. To take into account the features of choice at children|kids| taking into account efficiency and safety of application of drugs.

  • to forecast and discover|exposes,shows,reveals,displays| on early stages indirect actions|acts| of drugs,
    to conduct their correction.

Theoretical questions to|by| the theme:

    1. Mechanisms of appearance of edema at different|diverse| clinical syndromes.

    2. Classification of diuretics |. Pharmakokinetic and mechanism of action|act| of every group of diuretics |.

    3. Grounds of choice of diuretics |, ways of using|input|, dose|regime| at cardiac|hearty,kind| insufficiency, hyperpiesis, glaucoma, at kidney and hepatic insufficiency.

    4. Interaction with other groups of preparations|. Prophylaxis and treatment of the second|secondary| hyperaldosteronism.

    5. Features of application of diuretics at different|diverse| age-dependent groups and at pregnancy.

    6. Side effects. Value|importance,meaning| of doses and duration of application|purpose| for effective and safeness therapy. Features of application of preparations which change tolerance| to|by| diuretics|.


Place|seat| and time of conducting of practical classes |occupation|

Practical classes |occupation| with students is conducted from 8.30 to 13.35. Practical classes are conducted in an educational room. Curation| of patients takes place in the department of therapeutic type|profile| of the Lugansk regional clinical hospital.

Rigging of practical classes|occupation|.

Tables, collections of preparations, booklets, «Methodical guides|indications| for students to|by| practical classes|occupations| from clinical pharmacology», «List|enumeration| of preparations and standards|models| of sample of writing of medical|medicinal| forms|shapes|».


Literature:

  1. Drug evaluations annual /J. Ambre, D. R. Bennet, J. W. Cranston et all.- New York: McGraw-Hill, 1994.- 2364 p.

  2. Goodman & Gilman’s the pharmacological basis of therapeutics.- 11th ed. / editor, Laurence L. Brunton; associate editor, John S.Lazo, Keith L.Parker. – New York: McGraw-Hill, 2006. – 2021 p.



METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASS № 2


Themes:

1. Clinical and pharmacological description of antianginal| and antiischemic preparations.

2. Clinical and pharmacological description of medical preparations which influence on a lipid exchange.


Duration of practical classes|occupation|: 6 hours

Actuality of theme: Ischemic heart trouble is|appears| one with the most widespread disease which|what| results in|to| invalidating| and high lethality of population of the developed countries. That is why|that is why| the study of pharmacological properties|virtues| of antianginal| | preparations with the purpose of rational medicinal treatment of ischemic heart disease| is|appears| very|highly| actual.


At the study of theme it is necessary to integrate with the following departments|pulpits|:

  • normal and pathology physiology;

  • pharmacology (mechanism action|act| of drugs)

  • department|pulpit| of propedeutic| of internal|inlying| disease (methods of research of diseases
    of the cardivascular| system)


Purpose general|common|: To learn|studies,learns| clinical pharmacology and criteria of efficiency and safety of antianginal| | preparations.


Concrete aims: To learn clinical and pharmacological description of antianginal| | preparations.

To know:

  • mechanism of action|act|, pharmacodynamic, pharmakokinetic of antianginal| | preparations;

  • indications and contrindications to application |purpose|, undesirable effects
    of afore-mentioned preparations, features of action|act| in the organism of old people, features of their application.

To be able:

- to conduct the adequate choice and to appoint|sets| the most effectiveness and safeness drugs at ischemic heart disease.

  • to determine the optimum mode|regime| of dosage, method of introduction|input| taking into account the pharmacodynamic, pharmakokinetic parameters of preparations, age,
    disease, concomitant pathology at a concrete patient;

  • to choose the most effectiveness and safeness combination|petticoat| of drugs;

  • to forecast and discover|exposes,shows,reveals,displays| on early stages undesirable effects
    of drugs and to conduct their correction.

Theoretical questions to|by| the theme:

1. Групи antianginal| | preparations.

2.Nitrates and nitrites: a pharmacodynamic, a pharmacokinetic, clinical application. Medical forms and a choice of preparations, undesirable effects.

3. Sidnoniminum|: pharmacodynamic, pharmakokinetic, clinical application.

4. Calcium channel blockers: pharmacodynamic, pharmakokinetic, clinical application.

5. Antiaggregants|: pharmacodynamic, pharmakokinetic, clinical application.


Actuality of theme is « Clinical and pharmacological description of medical preparations which influence on a lipid exchange»: violations of lipid| exchange (atherosclerosis) underlain development| of numerous diseases of the cardiovascular | and endocrine systems and very|highly| wide-spread|widespread| in a whole world. Consequently|so,thus|, there is a necessity in the careful study of pharmacodynamic, pharmakokinetic, interaction, undesirable effects of these drugs.


Purpose general|common|: To learn|studies,learns| clinical pharmacology of preparations which influence on a lipid exchange.

Concrete aims: To learn clinical and pharmacological description of hypolipidemic| drugs from different|diverse| groups.

To know:

  • ethiopathogenetical| links of development of atherosclerosis;

  • mechanism of action|act|, pharmacodynamic of hypolipidemic | preparations from different|diverse| groups;

  • indications and contrindications to application |purpose|, undesirable effects
    of afore-mentioned preparations, features of action|act| of drugs in the organism of old people, features of their application.

To be able:

- to conduct the adequate choice and to appoint|sets| the most effectiveness and safeness
hypolipidemic| drugs at cardiac|hearty,kind| insufficiency, hypertonia, glaucoma, at kidney and hepatic insufficiency;

  • to analyze the results of pharmakokinetic and pharmacodynamic
    of drugs;

  • to conduct the choice of drugs. To take into account the features of choice at children|kids| taking into account efficiency and safety of application of drugs.

  • to forecast and discover|exposes,shows,reveals,displays| on early stages indirect actions|acts| of drugs,
    to conduct their correction.


Theoretical questions to|by| the theme:

  1. Ethiopathogenetical | principles of treatment of atherosclerosis.

  2. Classification of hypolipidemic| drugs|.

  3. Ground of choice of preparation depending on the class of dislipidemiya |. Dose|regime|, interaction with other groups of preparations.

  4. Estimation|appraisal| of efficiency and safety of application.

  5. Side effects|act| of preparations.


Place|seat| and time of conducting of practical classes |occupation|

Practical classes |occupation| with students is conducted from 8.30 to 13.35. Practical classes are conducted in an educational room. Curation| of patients takes place in the department of therapeutic type|profile| of the Lugansk regional clinical hospital.


Rigging of practical classes|occupation|.

Tables, collections of preparations, booklets, «Methodical guides|indications| for students to|by| practical classes|occupations| from clinical pharmacology», «List|enumeration| of preparations and standards|models| of sample of writing of medical|medicinal| forms|shapes|».


Literature:

  1. Drug evaluations annual /J. Ambre, D. R. Bennet, J. W. Cranston et all.- New York: McGraw-Hill, 1994.- 2364 p.

  2. Goodman & Gilman’s the pharmacological basis of therapeutics.- 11th ed. / editor, Laurence L. Brunton; associate editor, John S.Lazo, Keith L.Parker. – New York: McGraw-Hill, 2006. – 2021 p.

METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASS № 3


Themes:

1. Clinical and pharmacological description of medical preparations |, which influence on the bronchial admittance |passable|.

2. Clinical and pharmacological description of antibacterial medical preparations |.


Duration of practical classes|occupation|: 6 hours

Actuality of theme «Clinical and pharmacological description of medical preparations |, which influence on the bronchial admittance |passable|»: importance of an investigated theme for the doctor is determined by an opportunity of effective treatment and the prevention of development of diseases of bronchuses and lungs. A pathogenesis of these diseases in each concrete case struggle for its life, convalescence and an after treatment has prominent features without taking into account which effective medical correction of a condition of the patient is impossible. Application ЛС which change a condition of a bronchial tree, has multipurpose purpose, in connection with their influence on pathophysiological mechanisms of disturbances of a vascular tonus, a hydropic syndrome, syndromes of disturbances of a rhythm of heart and conduction, etc. the Great value has application of these preparations at a pathology with the specified syndromal disturbances. Skill truly to be guided in mechanisms of action of preparations, is scientifically based to use them for correction diseases, to apply medicinal therapy as a method of verification of the diagnosis - forms clinical thinking of the future expert.

Studying of the presented theme allows students to master effectively a various pathology, to form clinical outlook and to use the received knowledge in practical activities.


At the study of theme it is necessary to integrate with the following departments|pulpits|:

  • normal and pathology physiology;

  • pharmacology (mechanism action|act| of drugs)

  • department|pulpit| of propedeutic| of internal|inlying| disease (methods of research of diseases
    of the cardivascular| system)


Purpose general|common|: To learn students to scientifically proved approaches to rational choice of preparations to the concrete patient, methods of the objective control of efficiency and safety of their application. To learn students to skill effectively and safely to apply the medical preparations which are used at diseases of organs of respiration.

Concrete aims: To learn clinical and pharmacological description of preparations, which influence on the bronchial admittance.

To know:

- ethio-| and nosotropic verification of bronchial obstruction syndrome;

- basic|main| pathophisiological| mechanisms which characterize|describes| development of this
pathology and|appears| the object of the medicinal influencing;

- pharmakokinetic and pharmacodynamic description of basic|main|
representatives of preparations groups|, which|what| are used for treatment of bronchial obstruction syndrome:

- undesirable effects of preparations |;

- principles of combining of preparations |;

- criteria of efficiency and safety of application of offered preparations |.

To be able:

- to choose|chooses| and pick up preparations to the concrete patient| is needed;

- to select the criteria of estimation|appraisal| of therapeutic efficiency and safety
of applied preparations |;

- to re-done|accomplishes| the immediately| medicinal help: attack of bronchial
asthma, status asthmatics|figure,camp,mill|.


Theoretical questions to|by| the theme:

1. To count leading pathogenetic mechanisms which cause development and a course of a syndrome of bronchial obstruction,

2. To count disease and clinical syndromes which development is accompanied by disturbance of bronchial permeability.

3. What principles are put in a basis of classification of preparations which influence bronchial permeability?

4. Explain the mechanism of broncholytic actions of an adrenaline and ephedrine. To name undesirable effects on a background of their application.

5. Explain a way of application aerosolic bета-adrenomimetic and the mechanism of action of these preparations.

6. Prove necessity of purpose of glucocorticoids at bronchial asthma also note them pharmacodynamics features.

7. To list criteria of efficiency and safety of glucocorticoid therapy.

8. What underlies broncholitic action of analogues of an Euphyllinum? Note criteria of safety of these preparations.

9. Make a treatment planning and a conclusion of the patient of an asthmatic condition.

  1. Formulate value and rules of application of expectorating and mucolytic preparations, mechanisms of action.

  2. Lead indications to purpose at a syndrome of bronchial obstructions of antihistamine preparations: also characterize their mechanism and medical effect.


Actuality of theme «Clinical and pharmacological description of antibacterial medical preparations |»: Antimicrobial medical agents take a special place in modern medicine. They are object of studying of different biological and chemical sciences. The important problem{task} is creations of new preparations with the expressed etiotropic action which would be active concerning to proof forms of microorganisms and would render the minimal side effect on a macroorganism. The serious problem for practice is got with a resistance of microorganisms. The effect of a chemotherapy of infectious diseases in an essential measure depends on a combination of antibiotics with other antimicrobial medical agents (sulfanilamidums, nitrofuranums, chinolones etc.), and also agents which stimulate protective forces of the patient. Actual for clinic there are prevention{warning} and treatment of allergic reactions which arise at carrying out of antibacterial therapy.


At the study of theme it is necessary to integrate with the following departments|pulpits|:

  • medical biology;

  • biological chemistry;

  • microbiology;

  • pharmacology;


Purpose general|common|: To learn|studies,learns| clinical pharmacology and rational use in clinical practice of antimicrobial drugs|what|.


Concrete aims: To learn clinical and pharmacological description of antimicrobial drugs.


To know:

- mechanism of action, pharmacodynamics, pharmacokinetics of germicides;

- indications and contraindications to application;

- interaction between itself and other medical agents;

- undesirable effects of antimicrobic preparations, actions on their prevention and correction;

- features of application at children's age and at people of old age.

To be able:

  • to spend a rational choice of antimicrobial medical agents on the basis of the diagnosis, features of a course of disease, a condition of the patient;

  • to determine an optimum regimen of dosage, a way of introduction in view of

  • pharmacodynamic and pharmacokinetic parameters of preparations, age, a floor, disease, localization and a course of pathological process;

  • to spend an effective and safe combination of medical agents;

  • to prognosticate and show at early stages undesirable effects of a pharmacotherapy, and also to correct{adjust} arising complications;


Theoretical questions to|by| the theme:

  1. Classification of chemotherapeutic agents

  2. The basic mechanisms of action of antibiotics. Principles of classification, a choice of a preparation, a way and a regimen of introduction.

  3. Group of Penicillinum: the mechanism and a spectrum of antimicrobic action of the basic preparations, a pharmakokinetics, undesirable effects, their prophylaxis and correction.

4. Cephalosporins. Clinical application.

5. Macrolides, the characteristic, application.

  1. Aminoglycosides, spectrum of antibacterial action, undesirable effects, their prophylaxis and correction.

  1. Tetracyclinums, spectrum of action, feature of application in a pediatric practice.

  2. Chloramfenicolums, clinical application.

  1. Sulfanilamidums: classification, the mechanism and a spectrum of antimicrobial action, Dosage, prophylaxis of complications.

10. Nitrofuranus: the mechanism and a spectrum of antimicrobial action, clinical applications and undesirable effects.

11. Principles of the combined treatment by germicides.

12. Features of application of antimicrobial medical agents at children and pregnant women.


Situational tasks

1. 1. The patient, 23 years, has arrived in unit with the diagnosis - right-hand bronchopneumonia. From the anamnesis it is known, that the patient from 8 years suffers an infectious-allergic bronchial asthma. Attacks are provoked by a book and house dust. For a cupping of attacks uses: theophedrinum which accepts on 10 tab. in day. On a background of clinic of a basic disease at the patient attributes of the expressed syndrome of bronchial obstruction and an overdosage of theophedrinum are observed. Offer a treatment planning of the basic and accompanying diseases with the indicating of concrete preparations, their doses, ways of introduction.

2. The Patient, 53 years, during 10 years suffers a bronchial asthma, a chronic bronchitis. Marks annual exacerbations during the autumn and winter period. At unit has arrived in a condition of the asthmatic status. Objectively: respiration frequent (40 in min), loud, whistling. Above lungs plural dry whistling and buzzing rhonchuses are auscultated. Percussionly - a bandbox sound. Cardiac activity rhythmical, the frequency of the heart beating -110 in 1 min, a BP -140/80 mm hg, cardiac sounds muffled. Mucous are cyanotic.

Offer a concrete treatment planning of the given patient with the indicating of preparations, their doses, ways and a regimen of introduction.

3. At the patient, 30 years, after a sting of a bee in area of an acantha of 7-th cervical vertebra there was an edema of the face, sharp difficulty of respiration, and then a unconsciousness. The CCR-120 in 1 min, a BP - 80/40 mm hg. Above lungs are auscultated dry whistling rhonchuses on plant louses of an expiratory dyspnoea {short wind}. Formulate the diagnosis. Present the plan of granting urgent to the medicamental help.

4. The Patient, 55 years, suffer an idiopathic hypertension of II stage, ischemic disease of heart, cardiosclerosis with a circulatory inefficiency 1 item, chronic bronchitis. Was engaged in a self-treatment: accepted Trazicor-80, Adelphanum, Euphyllinum. It is delivered in unit in occasion of a loss of consciousness which has arisen on a background increasing bronchospasm. At inspection - a neurologic symptomatology absent. On an electrocardiogram - acute changes in a myocardium it is not taped, BP-140/80 mm hg, the CCR - 82 in 1 minutes.

Name the probable reason of occurrence of a bronchospasm and unconsciousness, on a background of absence of clinical attributes of an exacerbation of a chronic obstructive bronchitis and attributes of an acute coronary pathology. Give concrete references on the further pharmacotherapy of the patient.


Place|seat| and time of conducting of practical classes |occupation|

Practical classes |occupation| with students is conducted from 8.30 to 13.35. Practical classes are conducted in an educational room. Curation| of patients takes place in the department of therapeutic type|profile| of the Lugansk regional clinical hospital.


Rigging of practical classes|occupation|.

Tables, collections of preparations, booklets, «Methodical guides|indications| for students to|by| practical classes|occupations| from clinical pharmacology», «List|enumeration| of preparations and standards|models| of sample of writing of medical|medicinal| forms|shapes|».


Literature:

  1. Drug evaluations annual /J. Ambre, D. R. Bennet, J. W. Cranston et all.- New York: McGraw-Hill, 1994.- 2364 p.

  2. Goodman & Gilman’s the pharmacological basis of therapeutics.- 11th ed. / editor, Laurence L. Brunton; associate editor, John S.Lazo, Keith L.Parker. – New York: McGraw-Hill, 2006. – 2021 p.



METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASS № 4


Themes:


1. Clinical and pharmacological description of medical preparations |, which influence on the functions of gastrointestinal tract.

2. Clinical and pharmacological description of medical preparations |, which influence on the hepatobiliaric| system and pancreas.


Duration of practical classes|occupation|: 6 hours

Actuality of themes: diseases of an esophagus, a stomach, duodenum, a thin and thick intestine, as a rule, are accompanied by disturbance of their physiological functions. The correct estimation of character and a degree of dissonances of a functional condition is the basis for their effective medicamental correction. In a complex of medical actions the leading part belongs to remedies which normalize secretory and motor functions. Effective correction of these functions is a necessary condition of positive dynamics of disease, faster convalescence, remission, restoration of a working capacity. Diseases of a liver and a cholic bubble represent the big section of a pathology with which doctors of many specialities (therapists, surgeons) collide. In a liver there are basic transformations ЛС which are exposed to a metabolism, their inactivation, occurrence of biological activity and even toxicity for an organism. On the other hand, ЛС are capable to cause lesions of a liver (a toxic hepatitis, a chronic active and cholestatic hepatitis). Formation and a biliation, disturbance of functions of a cholic bubble can accompany with diseases of a hepatic parenchyma, and also again cause its damage. At disease of a cholic bubble there are acute conditions when it is necessary to render the help to the patient. Necessity of knowledge of basic groups of remedies which improve function of hepatic cells, and also skills to apply them in the concrete patient, depending on character and currents of pathological process determine importance of this theme.


Purpose general|common|: to learn students to scientifically proved approaches to rational choice of the remedies to the concrete patient, methods of the objective control of efficiency and safety of their application.


Concrete aims: To learn clinical and pharmacological description of preparations, which influence on the functions of gastrointestinal tract, hepatobiliaric| system and pancreas.

To know:

  • the unified algorithm of a choice of a pharmacotherapy, the control of its efficiency and safety; An etiology, a pathogenesis of disturbances of motor, secretory function of gastrointestinal tract, etio-and pathogenetic classification of a peptic ulcer, etc.; acute and chronic lesions of a liver; diseases of a cholic bubble, желчевыводных ways, a pancreas;

  • the basic pathogenetic mechanisms which are object of medicamental influence at the listed pathology;

  • pharmacokinetic and pharmacodynamic characteristic of the basic representatives of preparations groups, which are applied to normalization of functions of a digestive tube:

  • undesirable effects of remedies; principles of their combination; Criteria of efficiency and safety of application of preparations


To be able:

  • to choose to the concrete patient necessary preparations;

- to allocate criteria of an estimation of therapeutic efficiency and safety applied preparations;

- to render the differentiated medicamental help at: an acute painful syndrome at an exacerbation of a peptic ulcer, intestinal colic.


Theoretical questions to|by| the theme

1. Determine clinico-pharmacological principles of choice of preparations at hyperacid, hypoacid conditions, disturbances of motor function of gastrointestinal tract.

2. What principles are put in a basis of classification of antiulcerous drugs?

  1. Prove value of Atropinum at the intestinal colic increased of secretory activity of a stomach and specify probable by-effects at its application.

  2. Н2- histaminoblocers: the mechanism of action, the indication to application, contraindications, a side effect.

5. Determine the purpose of purpose at a peptic ulcer of a stomach and 12-перстной intestines of a preparation of a colloid bismuth - де-нола, specify by-effects.

6. Give clinico-pharmacological characteristic to remedies which improve a trophicity and neogenesis of a mucosa gastrointestinal tract.

  1. Explain the mechanism of action of laxatives of a natural and synthetic parentage, lead the indication to their purpose.

  2. Prove purpose drugs depending on a stage of a hypoacid gastritis. Characterize the mechanism of action.

  3. What is necessary in a basis of classification of remedies which will neutralize a hydrochloric acid?

  1. Explain necessity of purpose for complex treatment ulcerative

  2. Give clinico-pharmacological characteristic to remedies which appoint at an intestinal dysbacteriosis.

  3. Determine a circle of indications for purpose of biological eubiotics.

13. Improvement that you expect processes of a pharmacokinetics at use hepatotropic remedies?

14. Explain features of a pharmacodynamics of Essentiale. Select and prove a way of introduction.

  1. At gall-stone disease a probable conservative method of treatment. Explain its pathogenetic mechanisms, name corresponding remedies.

  1. Name the major choleretics of a phytogenesis.

  2. Make the plan of the urgent help at a hepatic colic. What preparation cannot be applied in this case, explain the reason.


Situational tasks

1. The patient, 26 years, has arrived in therapeutic unit with the diagnosis: exacerbations of a peptic ulcer of the duodenum with expressed painful and a dyspepsia’s syndrome. In complex therapy to the patient a solution on 0,5 ml subcutaneously 2 times Atropinum of 0,1 % enters into day. In a week the painful syndrome and a heartburn have considerably decreased, thus there was a dryness in a mouth, to a nose, vision has a little worsened.

Assess pharmacodynamics of Atropinum. What further tactics of application of the given preparation?

2. The patient, 32 years, has arrived on treatment with the diagnosis: a peptic ulcer with localization of a ulcer in a bulb 12-перстной intestines. At fractional research of gastric contents the established{installed} rising of gastric secretion (basal and stimulated), a high level of acidity. At an endoscopy - presence of a chronic ulcer with a vessel which bleeds. Determine effective preparations for treatment of the given disease, their dose, time and frequency rate of introduction, duration of treatment.

3. The Patient, 43 years, are on treatment in gastrointestinal unit in occasion of an exacerbation of a peptic ulcer in the duodenum. At research established rising of acidity of gastric contents, presence Н.руlіогі. make a choice of preparations which will cause a cicatrisation of a duodenum ulcer, specify their effective dose, time and frequency rate of receptions, duration of treatment.

4. The Patient, 48 years, the engineer, on a functioning often happens on business trips, has addressed in an out-patient department in occasion of an exacerbation of a chronic gastritis. Disturbed pains in to a epigastria site after reception of nutrition, depression of appetite, an eructation a smell of the eaten nutrition. At research gastric to juice the taped depression of secretory function of a stomach, at phybrogastroscopy - attributes of the moderate atrophic process to a mucosa of a stomach. The doctor to the patient appoints inside diluted Acidum hydrochloricum with Pepsinum in a combination to Pancreatinum. In 2 weeks the condition of the patient has considerably improved; from complaints remains feelings of gravity in epigastria area after reception of nutrition.

In the further to the patient it is recommended to continue on a background of keeping of a diet reception only diluted Acidum hydrochloricum during reception of nutrition. Explain the purpose of purpose of the given preparations on І a stage of treatment of the patient. Explain further tactics of the doctor concerning the given patient.

5. The Child, 10 years, first aid in hospital has delivered in occasion of acute poisoning with an acetic essence. The doctor has entered subcutaneously 0,1 ml of a solution of Apomorphini Hydrochloridum of 1 %, has made a gastric lavage of 0,5 % a solution to tannin and has entered into a stomach through a probe 10 g the activated coal. However a condition of the patient shortly there were signs of a peritonitis and a progressing acidosis. Characterize tactics of the doctor and bring in it the corrective amendments.

  1. At the patient with a portal cirrhosis of a liver the right-hand pneumonia has developed. Application of Penicillinum in a dose on 1 million 6 times day has not given effect and for the third day the doctor has made a decision to begin treatment of erythromycin by Natrii phosphas in a dose on 0,2 г 2 times day intravenously. Assess a situation.

8. Select a preparation for treatment of a serious staphylococcal pneumonia in the patient with a chronic hepatitis: benzilpenicillinum sodium salt in a daily dose 20 million; benzilpenicillinum sodium salt in a daily dose 40 million; a doxycycline; Rifampicinum; Cefazolinum. Give the explanatory to your actions.

9. The Patient, 20 years, the student, one year ago has carried an infectious disease, The hypochondrium complains of paroxysmal pains in right. Objectively: sharply expressed pain at a palpation of a cholic bubble. At a cholecystography noted augmentation of a cholic bubble and retardation of evacuation. At ultrasonic research of organs of abdominal emptiness of research of a cholic bubble it is established{installed}, that after a trial breakfast the cholic bubble was emptied on 20 % from initial volume.

Your diagnosis? A variant of disease. What preparations which influence function of a cholic bubble the shown patient.


Place|seat| and time of conducting of practical classes |occupation|

Practical classes |occupation| with students is conducted from 8.30 to 13.35. Practical classes are conducted in an educational room. Curation| of patients takes place in the department of therapeutic type|profile| of the Lugansk regional clinical hospital.


Rigging of practical classes|occupation|.

Tables, collections of preparations, booklets, «Methodical guides|indications| for students to|by| practical classes|occupations| from clinical pharmacology», «List|enumeration| of preparations and standards|models| of sample of writing of medical|medicinal| forms|shapes|».


Literature:

  1. Drug evaluations annual /J. Ambre, D. R. Bennet, J. W. Cranston et all.- New York: McGraw-Hill, 1994.- 2364 p.

  2. Goodman & Gilman’s the pharmacological basis of therapeutics.- 11th ed. / editor, Laurence L. Brunton; associate editor, John S.Lazo, Keith L.Parker. – New York: McGraw-Hill, 2006. – 2021 p.



METHODICAL GUIDES FOR STUDENTS TO PRACTICAL CLASS № 5


Themes:


1. Clinical and pharmacological description of anti-inflammatory drugs|.

2. Final|total| control of the module.


Duration of practical classes|occupation|: 6 hours


Actuality of theme «Clinical and pharmacological description of anti-inflammatory drugs |»: Pharmacological regulation of inflammatory process belongs to number most challenges of a modern pharmacotherapy. In particular big complexities arise at treatment of rheumatic diseases which are caused by gravity of their pathogenesis, is frequent with an autoimmune component. This group totals close about 100 nosological units and according to the CART, makes 1/3 part of physical disability and 1/10 physical inabilities. Appreciable prevalence, a high level of an invalidism which arise owing to different inflammatory processes, puts a problem of their pharmacotherapy in number social, and studying of rational medicamental treatment of these patients in view of a pharmacodynamics, pharmacokinetics, interactions, undesirable effects of medical agents is rather actual. In connection with last problem essential value has search, creations and applications of selective resolvents


At the study of theme it is necessary to integrate with the following departments|pulpits|:

  • medical biology and histology (structure|building| of cellcell|, structure|building| and structure
    of connecting fabric);

  • pathoanatomy (pathomorphology of inflammation|lighting|);

  • microbiology (concept|notion| about immunity, allergy, features of autoimmune |
    diseases);

  • pharmacology (mechanisms of action|act| of drugs);


Purpose general|common|: To learn|studies,learns| clinical pharmacology and rational use of anti-inflammatory, immunodepressive drugs and immunomodulators|.


Concrete aims: To learn clinical and pharmacological description of anti-inflammatory, immunodepressive drugs and immunomodulators

To know:

- classification of antiinflammatory{anti-inflammatory} medical agents;

- mechanism of action, pharmacodynamics, pharmakokinetics on groups and in comparative aspect of nonsteroid and steroid resolvents, antirheumatoid agents of long action, agents which oppress and are stimulated with immune processes in children's and advanced age;

- undesirable effects, features of undesirable effects at children's age. Teratogenous and embriotoxic ability.

- interaction of preparations between itself and preparations of other groups;

- applications of resolvents at rheumatic, rheumatoid diseases and other pathology.

.

To be able:

- to spend a rational choice of anti-inflammatory medical agents on the basis of the diagnosis, features of a course of disease, a condition of the patient, an accompanying pathology;

- to prognosticate and show at early stages undesirable effects of a pharmacotherapy;

- to use a quality monitoring of efficiency and safety of treatment.


Theoretical questions to|by| the theme:

  1. Classification of anti-inflammatory.

  1. Pharmacodynamics and features of the mechanism of action of nonsteroid resolvents, phases of an inflammation which they influence.

  1. Groups of nonsteroid resolvents, their representatives.

  1. Features of the mechanism of action of selective nonsteroid resolvents.

  2. The comparative characteristic of anti-inflammatory, febrifugal, analgetic activity of the basic preparations of nonsteroid structure.

  3. Undesirable effects of nonsteroid resolvents, actions under their prevention{warning} and correction.

  1. The general mechanisms of anti-inflammatory action of glucocorticoids.

  2. Indications and contraindications to application of glucocorticoids.

  1. Complications at treatment by glucocorticoids and actions on them prevention.

10. Features of the mechanism of action of basic agents, indications to clinical application.

11. Side-effects of preparations of gold, Cuprenilum, their prevention.

12. Features of the mechanism of action of stimulators of immunologic processes. Indications to purpose.

13. Immunodepressants: classification, the mechanism of action, side effects, clinical application.


Place|seat| and time of conducting of practical classes |occupation|

Practical classes |occupation| with students is conducted from 8.30 to 13.35. Practical classes are conducted in an educational room. Curation| of patients takes place in the department of therapeutic type|profile| of the Lugansk regional clinical hospital.


Rigging of practical classes|occupation|.


Tables, collections of preparations, booklets, «Methodical guides|indications| for students to|by| practical classes|occupations| from clinical pharmacology», «List|enumeration| of preparations and standards|models| of sample of writing of medical|medicinal| forms|shapes|».


Literature:

  1. Drug evaluations annual /J. Ambre, D. R. Bennet, J. W. Cranston et all.- New York: McGraw-Hill, 1994.- 2364 p.

  2. Goodman & Gilman’s the pharmacological basis of therapeutics.- 11th ed./editor, Laurence L. Brunton; associate editor, John S.Lazo, Keith L.Parker. – New York: McGraw-Hill, 2006. – 2021 p.

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