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After consumption of rich food a patient has nausea and heartburn, steatorrhea. This
condition might be caused by:
A Bile acid deficiency
B Increased lipase secretion
C Disturbed tripsin synthesis
D Amylase deficiency
E Disturbed phospholipase synthesis
Galactosemia is revealed in the child. Concentration of glucose in the blood is not
considerably changed. Deficiency of what enzyme caused this illness?
A Galactose-1-phosphate uridyltransferase
Fatty of phospholipids is disordered due to fat infiltration of the liver. Indicate which of the
presented substances can enhance the process of methylation during phospholipids
B Ascorbic acid
Characteristic sign of glycogenosis is muscle pain during physical work. Blood examination
reveals usually hypoglycemia. This pathology is caused by congenital deficiency of the
A Glycogen phosphorylase
B Glucose 6-phosphate dehydrogenase
C Alpha amylase
D Gamma amylase
E Lysosomal glycosidase
An infant has apparent diarrhea resulting from improper feeding. One of the main diarrhea
effects is plentiful excretion of sodium bicarbonate. What form of acid-base balance disorder
is the case?
A Metabolic acidosis
B Metabolic alkalosis
C Respiratory acidosis
D Respiratory alkalosis
E No disorders of acid-base balance will be observed
Methotrexate (structural analogue of the folic acid which is competitive inhibitor of the
dihydrofolatreductase) is prescribed for treatment of the malignant tumour.On which level
does methotrexate inhibit synthesis of the nucleic acids?
A Mononucleotide synthesis
RNA-polymeraseB(II) is blocked due to amanitine poisoning (poison of death-cup). It
A Synthesis of m-RNA
B Synthesis of t-RNA
C Reverse transcription
D Primers synthesis
E Maturation of m-RNA
Pain along large nervous stems and increased amount of pyruvate in the blood were revealed
in the patient. Insufficiency of what vitamin can cause such change?
D Pantothenic acid
Patient with encephalopathy was admitted to the neurological in-patient department.
Correlation of increasing of encephalopathy and substances absorbed by the bloodstream
from the intestines was revealed. Whatsubstances that are created in the intestines can
Examination of a patient suffering from cancer of urinary bladder revealed high rate of
serotonin and hydroxyanthranilic acid. It is caused by excess of the following amino acid in the
A mother consulted a doctor about her 5-year-old child who develops erythemas, vesicular
rash and skin itch under the influence of sun. Laboratory studies revealed decreased iron
concentration in the blood serum, increased uroporphyrinogen I excretion with the urine. What
is the most likely inherited pathology in this child?
A Erythropoietic porphyria
C Hepatic porphyria
E Intermittent porphyria
A 3 year old child with fever was given aspirin. It resulted in intensified erythrocyte haemolysis.
Hemolytic anemia might have been caused by congenital insufficiency of the following
A Glucose 6-phosphate dehydrogenase
B Glucose 6-phosphatase
C Glycogen phosphorylase
D Glycerol phosphate dehydrogenase
Blood of a 12 year old boy presents low concentration of uric acid and accumulation of
xanthine and hypoxanthine. This child has genetic defect of the following enzyme:
A Xanthine oxidase
D Ornithine carbamoyltransferase
Increased amount of free fat acids is observed in the blood of the patients with diabetes
mellitus. It can be caused by:
A Increased activity of triglyceridelipase adipocytes
B Storage of palmitatoil-CoA
C Activation of the ketone bodies utilization
D Activation of the synthesis of the apolipoproteins
E Decreased activity of phosphatidylcholine-cholesterol-acyltransferase blood plasma
A 46-year-old female patient has a continuous history of progressive muscular (Duchenne's)
dystrophy. Which blood enzyme changes will be of diagnostic value in this case?
A Creatine phosphokinase
B Lactate dehydrogenase
C Pyruvate dehydrogenase
D Glutamate dehydrogenase
E Adenylate cyclase
A patient is ill with diabetes mellitus that is accompanied by hyperglycemia of over 7,2
millimole/l on an empty stomach. The level of what blood plasma protein allows to estimate
the glycemia rate retrospectively (4-8 weeks before examination)?
A Glycated hemoglobin
D C-reactive protein
In case of enterobiasis acrihine - the structural analogue of vitamin $B_2$ - is administered.
The synthesis disorder of which enzymes does this medicine cause in microorganisms?
A FAD-dependent dehydrogenases
D NAD-dependet dehydrogenases
A 10-year-old girl often experiences acute respiratory infections with multiple spotty
haemorrages in the places of clothes friction. Hypovitaminosis of what vitamin is present at
Hydroxylation of endogenous substrates and xenobiotics requires a donor of protons. Which
of the following vitamins can play this role?
A Vitamin C
B Vitamin P
C Vitamin B6
D Vitamin E
E Vitamin A
The formation of a secondary mediator is obligatory in membrane-intracellular mechanism of
hormone action. Point out the substance that is unable to be a secondary mediator:
A 4 y.o. child with signs of durative proteinic starvation was admitted to the hospital. The signs
were as follows: growth inhibition, anemia, edemata, mental deficiency. Choose a cause of
A Reduced synthesis of albumins
B Reduced synthesis of globulins
C Reduced synthesis of hemoglobin
D Reduced synthesis of lipoproteins
E Reduced synthesis of glycoproteins
Researchers isolated 5 isoenzymic forms of lactate dehydrogenase from the human blood
serum and studied their properties. What property indicates that the isoenzymic forms were
isolated from the same enzyme?
A Catalyzation of the same reaction
B The same molecular weight
C The same physicochemical properties
D Tissue localization
E The same electrophoretic mobility
On some diseases it is observed aldosteronism with hypertension and edema due to
sodium retention in the organism. What organ of the internal secretion is affected on
A Adrenal glands
An experiment proved that UV-radiated cells of patients with xeroderma pigmentosum restore
the native DNA structure slower than cells of healthy individuals as a result of reparation
enzyme defection. What enzyme helps this process?
B RNA ligase
D DNA polymerase III
E DNA gyirase
A patient with suspicion on epidemic typhus was admitted to the hospital. Some arachnids
and insects have been found in his flat. Which of them may be a carrier of the pathogen of
A businessman came to India from South America. On examination the physician found that
the patient was suffering from sleeping-sickness. What was the way of invasion?
A As a result of bug's bites
B As a result of mosquito's bites
C With contaminated fruits and vegetables
D Through dirty hands
E After contact with a sick dogs
Tere is observed inhibited fibrillation in the patients with bile ducts obstruction, bleeding due
to low level of absorbtion of some vitamin. What vitamin is in deficit?
A 52 year-old patient with bronchial asthma was treated with glucocorticoids. Fever reaction
appeared as a result of postinjective abscess. The patient had subfebrile temperature, which
didn’t correspond to latitude and severity of inflammatory process. Why did patient have low
A Inhibited endogen pyrogens production
B Violation of heat loss through lungs
C Inflammatory barrier formation in injection place
D Violation of heat-producing mechanisms
E Thermoregulation center inhibition
A 35-year-old man under the treatment for pulmonary tuberculosis has acute-onset of right
big toe pain, swelling, and low-grade fever. The gouty arthritis was diagnosed and high
serum uric acid level was found. Which of the following antituberculosis drugs are known for
causing high uric acid levels?
E Aminosalicylic acid
During metabolic process active forms of the oxygen including superoxide anion radical are
formed in the human body. With help of what enzyme is this anion activated?
A Superoxide dismutase
A patient presents high activity of LDH1,2, aspartate aminotransferase, creatine
phosphokinase. In what organ (organs) is the development of a pathological process the
A In the heart muscle (initial stage of myocardium infarction)
B In skeletal muscles (dystrophy, atrophy)
C In kidneys and adrenals
D In connective tissue
E In liver and kidneys
Buffer capacity of blood was decreased in the worker due to exhausting muscular work. Entry
of what acid substance to the blood can this state be explained?
While examining the child the doctor revealed symmetric cheeks roughness, diarrhea,
disfunction of the nervous system. Lack of what food components caused it?
A Nicotinic acid, tryptophane
B Lysine, ascorbic acid
C Threonine, pantothenic acid
D Methionine, lipoic acid
E Phenylalanine, pangamic acid
A13-year-old boy complains of general weakness, dizziness, tiredness. He is mentally
retarded. Increased level of valine, isoleucine, leucine is in the blood and urine. Urine has
specific smell. What is the diagnosis?
A Maple syrup urine disease
B Addison's disease
E Graves' disease
Increased breaking of vessels, enamel and dentine destruction in scurvy patients are caused
by disorder of collagen maturing. What stage of modification of procollagen is disordered in
A Hydroxylation of proline
B Formation of polypeptide chains
C Glycosylation of hydroxylysine residues
D Removal of C-ended peptide from procollagen
E Detaching of N-ended peptide
A 62-year-old female patient has developed a cataract (lenticular opacity) secondary to the
diabetes mellitus. What type of protein modification is observed in case of diabetic cataract?
E Limited proteolysis
Aspirin has antiinflammatory effect due to inhibition of the cyclooxygenase activity. Level of
what biological active acids will decrease?
D Biogenic amines
At the aboratory experiment the eukocyte culture was mixed with staphylococci. Neutrophile
leukocytes engulfed and digested bacterial cells. This processes are termed:
D Facilitated diffusion
Examination of a patient revealed typical presentations of collagenosis. This pathology is
characterized by increase of the following urine index:
D Mineral salts
E Ammonium salts
Marked increase of activity of МВ-forms of CPK (creatinephosphokinase) and LDH-1 were
revealed on the examination of the patient's blood. What is the most likely pathology?
A Miocardial infarction
Untrained people often have muscle pain after sprints as a result of lactate accumulation.
This might be caused by intensification of the following biochemical process:
C Pentose phosphate pathway
A 16-year-old boy was performed an appendectomy. He has been hospitalized for right lower
quadrant abdominal pain within 18 hours. The surgical specimen is edematous and
erythematous. Infiltration by what of the following cells is the most typical for the process
ATP synthesis is totaly blocked in a cell. How will the value of membrane rest potential
A It will disappear
B It will be slightly increased
C It will be considerably increased
D First it will increase, then decrease
E First it will decrease, then increase
The concentration of albumins in human blood sample is lower than normal. This leads to
edema of tissues. What blood function is damaged?
A Maintaining the oncotic blood pressure
B Maintaining the Ph level
C Maintaining the body temperature
D Maintaining the blood sedimentation system
E All answers are correct
Examination of a patient suffering from frequent haemorrhages in the inner organs and
mucous membranes revealed proline and lysine being included in collagen fibers.
Impairment of their hydroxylation is caused by lack of the following vitamin:
A 20 year old patient complains of general weakness, dizziness, quick fatigability. Blood
analysis results: Hb- 80 g/l. Microscopical examination results: erythrocytes are of modified
form. This condition might be caused by:
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