Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity icon

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity




НазваClinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity
Дата14.07.2012
Розмір5.5 Kb.
ТипДокументи

CLINICAL, FUNCTIONAL PECULARITIES AND THE LEVEL OF C-REACTIVE PROTEIN IN PATIENTS WITH OSTHEOARTHRITIS AND OBESITY

Opimakh O.I., Dytko V.V.

Science chief – M.D. L.N. Prystupa

Sumy State University, Department of Internal Medicine postgraduate education with propedeutics course


Study was aimed to find out with functional changes and the level of C-reactive protein (CRP) in patients with osteoarthritis (OA) and obesity.

Material and methods. 135 patients with OA: I group included 42 patients with normal body weight (NMT), II - 93 OA patients with obesity, control - 24 healthy persons with NBW.

Obesity was diagnosed according to WHO criteria (1999). Examination included determination of CRP level, Leken and WOMAC index. Statistical processing of results was carried out using licensed Microsoft Office 2000.

Results. Analysis of Leken index showed that OA was more severe in patients of the second group (16,40,26) compared with patients group I (8,80,28) (p<0,05). In fact OA patients with obesity had more pronounced level of pain by WOMAC scale (56,20,78) compared with OA patients with NBW (47,30,97) (p<0,001), stiffness (57,30,56) to (53,40,84) (p <0,001).

In addition, research of CRP content as a marker of systemic inflammation activity, showed that in patients of the first group level was (5,30,28) mg/l (p<0.05) against (4,60,11) mg/ml in the control and (7,20,38) mg/l (p<0,001) in the second group of patients. In OA patients with obesity we found close positive correlation between CRP and body mass index (r=0,67; p<0,001) between CRP and capacity of visceral adipose tissue (r = 0,69; p<0,01). In patients with CRP levels and obesity has been linked expression of pain, confirmed the close correlation (r = 0,62; p <0,05). So, feeling pain in OA patients is obviously the result of inflammation, confirmed the link between pain and the level of CRP.

Conclusions

1. Obesity has a negative impact on the joint syndrome in patients with OA, as evidenced by an increase in the pain syndrome, stiffness, functional changes in the Lekens index.

2. CRP levels in patients with OA are closely correlated with body mass index, visceral adipose tissue capacity and with severity of the pain that proves the role of adipose tissue as a producer of markers of inflammation in OA flow burden.

Схожі:

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconM. Gorky Donetsk National Medical University Technique Guidelines for the students’ individual preparation for
С-reactive protein, streptococcus antibodies titers and antistreptolysin o (Departments of Propedeutical Therapy, Physiology and...
Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconContents Clinical resarches
...
Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconGrants projects Studying, training and practice abroad
Всв109, іііb/IV, a randomized, placebo controlled clinical trial to avaluate cardiovascular outcomes after treatment with Exenatide...
Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconTheme: Early gestosis. Clinical course, diagnosis, treatment, prevention. Vomiting in pregnancy. Clinical examination of pregnant women.

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconThematic plan At Bases of clinical madicine for the third year foreign students of pharmacology faculty of vnmu (clinical pharmaceutics) for the V semester of 2012-2013 educational years. № п/п

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconCalendar plan of practical classes at Basics of clinical madicine for third year foreign students of pharmacology faculty of vnmu (clinical pharmaceutics) at V semester of 2012-2013 educational years.

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconClinical and epidemiological features of diphtheria
Хх century it was it is interrupted in 1991-1992 sharp getting up, that put under a doubt efficiency specific prophylaxis this disease....
Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconTheme 16. Reactive psychoses. Posttraumatic stress disorder

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconAbsorbent and dispersive pecularities of man’s lung condensant and its parts

Clinical, functional pecularities and the level of c-reactive protein in patients with ostheoarthritis and obesity iconThe structural and functional unit of the nervous system is

Додайте кнопку на своєму сайті:
Документи


База даних захищена авторським правом ©zavantag.com 2000-2013
При копіюванні матеріалу обов'язкове зазначення активного посилання відкритою для індексації.
звернутися до адміністрації
Документи