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CLINICAL, FUNCTIONAL PECULARITIES AND THE LEVEL OF C-REACTIVE PROTEIN IN PATIENTS WITH OSTHEOARTHRITIS AND OBESITY
Opimakh O.I., Dytko V.V.
Science chief – M.D. L.N. Prystupa
Sumy State University, Department of Internal Medicine postgraduate education with propedeutics course
Study was aimed to find out with functional changes and the level of C-reactive protein (CRP) in patients with osteoarthritis (OA) and obesity.
Material and methods. 135 patients with OA: I group included 42 patients with normal body weight (NMT), II - 93 OA patients with obesity, control - 24 healthy persons with NBW.
Obesity was diagnosed according to WHO criteria (1999). Examination included determination of CRP level, Leken and WOMAC index. Statistical processing of results was carried out using licensed Microsoft Office 2000.
Results. Analysis of Leken index showed that OA was more severe in patients of the second group (16,40,26) compared with patients group I (8,80,28) (p<0,05). In fact OA patients with obesity had more pronounced level of pain by WOMAC scale (56,20,78) compared with OA patients with NBW (47,30,97) (p<0,001), stiffness (57,30,56) to (53,40,84) (p <0,001).
In addition, research of CRP content as a marker of systemic inflammation activity, showed that in patients of the first group level was (5,30,28) mg/l (p<0.05) against (4,60,11) mg/ml in the control and (7,20,38) mg/l (p<0,001) in the second group of patients. In OA patients with obesity we found close positive correlation between CRP and body mass index (r=0,67; p<0,001) between CRP and capacity of visceral adipose tissue (r = 0,69; p<0,01). In patients with CRP levels and obesity has been linked expression of pain, confirmed the close correlation (r = 0,62; p <0,05). So, feeling pain in OA patients is obviously the result of inflammation, confirmed the link between pain and the level of CRP.
1. Obesity has a negative impact on the joint syndrome in patients with OA, as evidenced by an increase in the pain syndrome, stiffness, functional changes in the Lekens index.
2. CRP levels in patients with OA are closely correlated with body mass index, visceral adipose tissue capacity and with severity of the pain that proves the role of adipose tissue as a producer of markers of inflammation in OA flow burden.
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