«The News Luhansk Taras Shevchenko National University: The Medical and Biological sciences» №17 (252), 2012 Contents icon

«The News Luhansk Taras Shevchenko National University: The Medical and Biological sciences» №17 (252), 2012 Contents




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«The News Luhansk Taras Shevchenko National University:

The Medical and Biological sciences»

17 (252), 2012


Contents

Biological sciences

Alhashimi Sadad, Sheiko V. I. Day’s monitoring of arterial pressure at hypertension illness

Skivka L. M., Rudyk M. P., Pozur V. V., Tanasienko O. A.,
Boychenko P. K.
Effect of pathogen-associated molecules on expression of endogenous alarmins HMGB1 by murine peritoneal macrophages: relation to oxidative metabolism

Boyarchuk E. D., Lunina N. V. Histochemical features of neutrophils in the DIC

Buchko O. M. Antioxidant system of sow’s organism

Havrylyak V. V. Morphostructural and chemical changes of wool fiber in norm and pathology

Guzhva E. I. State of system immunity and biochemical indexes of sportsmen’s organism at the use of vilozen

Drel V. F. Influence of the daily dosed physical loading on functional liver reserve

^ Efremova U. P., Lychkovska N. E., Fafula R. V., Vorobets Z. D. Infrigment and correction of nitric oxide metabolism under rheumatoid arthritis

Ibatulina Yu. V. Dynamics of the age profile of the coenopopulations steppe species of plants in regional landscape «Park Zuevsky» (Donetsk region)

^ Iskra R. Ja. Antioxidant and immune-defence system of female rabbits under action of chromium chloride

Kozytska T. V., Morgun O. I. Comparetive Analisys of Morphological Disturbances of the Brain Cerebral Cortex Mice in Conditions CdS (4 – 8 nm) Nanoparticles and CdCl2 Salt Administration

^ Kostenko O. R., Shmalyey S. V., Redka I. V. The Immunological features of children with sensorineyral relative deafness different etiology

Lobko S. A. Effect of alkilselenonaphtiridin on adaptation of the heart to chloroform intoxication

Maslova O. O. Selection of the optimal medium supplement for umbilical cord derived mesenchymal stem cells culturing

^ Matvienko M. G., Pustovalov A. S., Buzynska N. O.,
Dzerzhinsky M. E.
Morphofunctional changes in prepubertal rat testes under kisspeptin influence against blockade and activation of alpha-adrenergic receptors and melatonin administration

Mishchenko L., Dunich A., Veselsky S., Sereda O. Hypoglycemic effects of herbs extracts and their mixture under alloxan-induced diabetes

^ Nosal O. V., Liubanova O. P., Shuba Y. M. Complex modulation of Cav3.1 T-type calcium channel by nickel

Orzulova E. V., Vinogradov A. A. Anatomic variability of bulge of external surface and depth of concavity of internal surface of human parietal bone

^ Ropaeyva M. А., Sheyko V. I., Boyarchuk E. D. Influence of adaptation reactions on system immunity and homoeostasis

Skripnik N. N., Ivanyura I. A., Razdaybedin V. N., Lysenko S. G., Boyarchuk E. D. Adaptation of the respiratory system to physical stress

Sokolenko V. L., Sokolenko S. V. Values of T-cellular immunityIn patients, who long lived inRadioactive contaminated territory

^ Fafula R. V., Lychkovska N. E., Efremova U. P., Vorobets Z. D.
Ca2+-Mg2+-ATP-ase enzyme activity in peripheral blood lymphocytes in patients with spondyloarthritis

Khudyakova O. V. Anatomic changeability of structure of eye socket of people of ХХ of century

^ Chernyak Е. A., Avad Ali Riyadkh. Features of experimental design of saccharine diabetes

Sheiko V. I. The state of the neurodynamic functions and immune system during the Vilosenum appliance for the people with the myopia


Medical sciences

Vinogradov O. A. Experimental modeling of Traumatic Brain Injury

Gavreluk S. V., Boyarchuk Е. D., Levenets S. V. The estimation of length of free lower limb for children of the period of the first childhood of the beginning of XXІ century by comparison to data of children of the beginning of XX century

Glazkov Е. А. To question of study of adaptation of students at studies in higher educational establishments

Gromchenko Yu. А. GGT used for screening for viral hepatitis in prevention inspections

^ Knyshov G. V., Lazoryshynets V. V., Rudenko K. V.,
Rasputnyak O. V., Plyska A. I.
A new in the clinical classification and strategy of treatment of the hypertrophic cardiomyopathy

Resunenko Y. K., Prokopov V. A. State of enzyme systems bioenergetic processes in rats at conditions of prolonged influence of polyols structurally based on glycerol

Savina A. V. Exposition dynamics of sorption of the liver in acute pancreatitis

^ Tsarev A. A., Kosharny V. V., Abdul-Ogli L. V. The structural changes in limb muscles of rats with damage to the femoral and sciatic nerves


CONTENTS


Biological sciences

Alhashimi Sadad, Sheiko V. I. Day’s monitoring of arterial pressure at hypertension illness

Depending on the sizes of average daily variability of arterial pressure patients parted on sub-groups: with normal and enhanceable variability of arterial pressure. At the values of variability systole / diastole arterial pressure, exceeding 15 / 12 mm Hg accordingly, variability of arterial pressure considered as enhanceable, at the less values of variability of arterial pressure considered as normal.

^ Key words: arterial hypertension, variability of arterial pressure.


Skivka L. M., Rudyk M. P., Pozur V. V., Tanasienko O. A., Boychenko P. K. Effect of pathogen-associated molecules on expression of endogenous alarmins HMGB1 by murine peritoneal macrophages: relation to oxidative metabolism

It was shown that structural and secretory pathogen-associated molecules cause decrease of endogenous alarmins HMGB1 release accompanied by augmentation of extracellular reactive oxygen specie generation. Inversely proportional dependence of alarmin release on extracellular reactive oxygen species level was registered.

^ Key words: endogenous alarmins HMGB1, reactive oxygen species, pathogen-associated molecules.


Boyarchuk E. D., Lunina N. V. Histochemical features of neutrophils in the DIC

Revealed histochemical changes of blood neutrophils in DIC-syndrome. Increased activity of marker enzymes – acid phosphatase in serum was accompanied by the decrease in the number of granules in the cytoplasm of neutrophils, and degranulation was associated with azurophilic granulation. With that, the stage was dominated by neutrophils, hypercoagulation, containing up to 10 grains, and the stage of hypocoagulation was the largest group of neutrophils containing less than 10 grains. Maximal degranulation and activity of acid phosphatase were observed in a time of profound disorders of hemostasis in DIC-syndrome.

^ Key words: neutrophils, degranulation, azurophilic granularity, acidic phosphataze, DIC.


Buchko O. M. Antioxidant system of sow’s organism

The data about the antioxidant defence system and free radical reactions in sows’ organisms at the end of farrowing and during lactations were presented. It was established increasing of lipid hydroperoxides content and decreasing of enzymatic activity of antioxidant defence system (superoxide dismutase, katalase, glutathione peroxidase and glutathione reductase) in the blood of sows for 25 days after farrowing compared to the period before farrow. These data indicate the development of stress in their organism and weakening the protective mechanisms of adaptation during farrowing and lactations.

^ Key words: antioxidant system, sows, oxidative stress.


Havrylyak V. V. Morphostructural and chemical changes of wool fiber in norm and pathology

The data about morphostructural and chemical changes of normal and pathologically thin wool fibers were presented. It was established abnormal thinning hair is accompanied by the redistribution of the structural components of fiber in particular decrease of proteins with a high sulfur content and increase of low sulfur proteins. This wool is also characterized by chemical changes such as higher concentrations of cystine and SH-groups and lower content of cystine. Thus, the thinning fibers mechanism is associated mainly with the imbalance of sulfur compounds.

^ Key words: wool fiber, thinning, morphostructure.


Guzhva E. I. State of system immunity and biochemical indexes of sportsmen’s organism at the use of vilozen

For today considerable attention is paid to the study of mechanisms of co-operation of the immune and endocrine systems in condition of adaptation to the physical loadings which was accompanied by disfunction of system immunity, namely by the secondary immunodeficiency. It testifies to actuality of scientific researches in such direction of physiology, as co-operation of functions of the systems of immunity and indexes of homoeostasis for people who regularly go in for sports in the conditions of activating of cellular link system immunity. Activating of cellular link system immunity for sportsmen carries immunorehabilitation character, improves adaptation backlogs and possibilities of organism.

^ Key words: disfunction, immunostimulant, vilozen, homoeostasis, biochemical indexes.


Drel V. F. Influence of the daily dosed physical loading on functional liver reserve

The research has been carried out on white male rats which were daily subjected to physical loading in the revolved drum. The functional reserve of liver was studied by data of portal blood flow which was determined by ultrasonic dopplerographe. It is set that the indexes of portal blood flow changed after the physical loading, that negative influence index of portal blood flow had rendered which was below 1,0. It is possible to conclude, that the indexes of functional reserve of liver go down in the conditions of the daily physical loading.

Keywords: physical loading, functional reserve of liver.


^ Efremova U. P., Lychkovska N. E., Fafula R. V., Vorobets Z. D. Infrigment and correction of nitric oxide metabolism under rheumatoid arthritis

The enzyme activity of NO synthase of peripheral blood lymphocytes of donors and patients with rheumatoid arthritis has been studied. It showed the significant descrease of eNO synthase activity and significant increase of iNO synthase activity in peripheral blood lymphocytes of patients with rheumatoid arthritis in comparison with healthy donors. The dynamics of NO-synthase enzyme activity is observed after patient’s treatment. The activity of both enzyme forms approaches their control values.

^ Key words: autoimmune disease, rheumatoid arthritis, NO-synthase, nitric monoxide, lymphocytes.


Ibatulina Yu. V. Dynamics of the age profile of the coenopopulations steppe species of plants in regional landscape «Park Zuevsky» (Donetsk region)

In steppe vegetative communities on coal slates and sandstone on abrupt slopes minor changes in structure of coenopopulations of steppe types of plants are carried out. They remain normal, mature. There are self-regulating systems which do not depend on drift of rudiments from out of. The factor which brakes negative changes in age structure, density of coenopopulations of steppe types of plants, is the soil.

^ Key words: coenopopulations, structure, phytocenose.


Iskra R. Ja. Antioxidant and immune-defence system of female rabbits under action of chromium chloride

The studies have found out that іn female rabbits during lactation by the action of chromium chloride at a dose of 4,5 µg Cr3+/kg body weight the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathionе reduktase and vitamin E increases, but the content of reduced glutathione and circulating immune complexes of antigen-antibody, indicating that increasing resistance of the organism decreased.

^ Key words: female rabbits, сhromium chloride, antioxidant system.


Kozytska T. V., Morgun O. I. Comparetive Analisys of Morphological Disturbances of the Brain Cerebral Cortex Mice in Conditions CdS (4 – 8 nm) Nanoparticles and CdCl2 Salt Administration

The article is dedicated to the new and perspective way of modern biomedical investigations – nanotoxicology. Nanomaterials today are widely used in different fields of industry, medicine etc. But the problem of their toxic effect isn’t still solved. It is important that in the article the authors compare the CdS nanoparticles, stabilizer (sodium polyphosphate) and pure salt (CdCl2) effects. The results of the investigation are very important for understanding the way how nanosized materials influence the embryonic development and the difference between the effect of cadmium in composition of nanoparticles and salt.

^ Key words: nanoparticles, cytotoxicity, embryotoxicity, embryogenesis, nervous system.


Kostenko O. R., Shmalyey S. V., Redka I. V. The Immunological features of children with sensorineyral relative deafness different etiology

In the article the relative quantity of lymphocytes of various subpopulation, where immunoglobulin’s and circulating immune complexes are compared on children with sensorineyral relative deafness (idiopathic and infectious) and healthy children. The sensorineyral relative deafness is accompanied by decrease in quantity of T-lymphocytes in subpopulations, IgA and IgM in comparison with the control. The infectious sensorineyral relative deafness as against idiopathic is accompanied by lower levels CD3+ and CD25+-lymphocytes, circulating immune complexes and more higher level IgG.

^ Key words: sensorineyral relative deafness, lymphocytes, immunoglobulin’s, circulating immune complexes.


Lobko S. A. Effect of alkilselenonaphtiridin on adaptation of the heart to chloroform intoxication

The research shows the positive effect of alkilselenonaphtiridin on structural and functional characteristics of heart ventricle myocardium in condition of chloroform intoxication. The activity of catalase of blood serum and heart ventricle myocardium, intensiveness of exposition sorption dynamic decreased. In result of histology examination it was revealed that a mass of heart ventricle myocardium and toxic influence of chloroform decreased.

^ Key words: alkilselenonaphtiridin, chloroform.


Maslova O. O. Selection of the optimal medium supplement for umbilical cord derived mesenchymal stem cells culturing

The selection of the best source of growth factors for mesenchymal stem cells’ (MSC) culturing is an actual task. The effects of a standard source of growth factors – fetal calf serum (FCS) and autologous and allogeneic platelet-rich plasma (PRP) on cultured human umbilical cord derived mesenchymal stem cells are compared in this paper. It is shown that the using of FCS is acceptable for the laboratory needs. Xenogenic elements should be excluded from the medium prior to the injection to patient. Cord blood-derived PRP or patients blood-derived PRP should be used in that case.

^ Key words: mesenchymal stem cells, cord matrix, fetal calf serum, platelet rich plasma.


Matvienko M. G., Pustovalov A. S., Buzynska N. O.,
Dzerzhinsky M. E. Morphofunctional changes in prepubertal rat testes under kisspeptin influence against blockade and activation of alpha-adrenergic receptors and melatonin administration


Activation of testicular function is revealed in prepubertal rats after kisspeptin administration both comparing to phisiological solution and in combination with prazosin and melatonin. In contrast, injections of kisspeptin receptor antagonist resulted inactivation of the gonads both comparing to phisiological solution and in complex with mezaton and melatonin.

^ Key words: testes, kisspeptin, mezaton, prazosin, melatonin.


Mishchenko L., Dunich A., Veselsky S., Sereda O. Hypoglycemic effects of herbs extracts and their mixture under alloxan-induced diabetes

Effect of extracts from 7 medicinal plants and 1 anti diabetic mixture on the rat organism under conditions of diabetes modulating with Alloxan is investigated. It was studied that all tested samples positive made effect on the rats organism and stabilized their drinking mode. All investigated medicinal plants decreased the content of glucose in the blood plasma of rats: agrimony, artichoke, blueberry and yacon (leaves) on the 36 %, anti diabetic mixture – on 48 %, clover – on 46 %, mulberry – on 44 % and yacon (root) – on 30 %.

Key words: medicinal plants, diabetes, Alloxan, glucose.


Nosal O. V., Liubanova O. P., Shuba Y. M. Complex modulation of Cav3.1 T-type calcium channel by nickel

In the present study we compared Ni2+-sensitivity of the wild-type (w/t) Cav3.1-channel with Cav3.1-mutant, in which glutamine (Q) in the position equivalent to the H191 of Cav3.2 was substituted for histidine
(Q172H mutant). Each channel was expressed in Xenopus oocytes and the blockade of Ca2+, Sr2+ or Ba2+ (10 mM each) current by Ni2+ was assessed by means of conventional double-microelectrode voltage-clamp technique. Our data indicate that inhibition of Cav3.1-channel and Cav3.1-mutant is indeed determined by Ni2+ binding with two sites – high-affinity and low affinity.

^ Key words: T-type calcium channels, Xenopus oocytes, Ni2+.


Orzulova E. V., Vinogradov A. A. Anatomic variability of bulge of external surface and depth of concavity of internal surface of human parietal bone

The length of chord, curve of external surface and depth of concavity of internal surface human parietal bone depended on skull shape and sex. It is revealed that the bulge of external surface of parietal bone was more in female human beings than in male ones in most cases. The authors proposed a hypothesis that the volume of parietal lobe of brain was more in women than in men. It can have influence on a sensory sensitiveness.

Keywords: parietal bone, craniometry.


^ Ropaeyva M. А., Sheyko V. I., Boyarchuk E. D. Influence of adaptation reactions on system immunity and homoeostasis

To revolting stress influences which present the substantial threat of origin of the dysbalance state of homoeostasis, sporting activity can be taken. From data of modern researches the physical loadings are accompanied by dysfunction of system immunity, which is the second immunodeficiency state, characterized the changes of some indexes blood, prevails at. Also changes of exchange macro- and oligoelements, indexes of electrolytes of blood are observed.

^ Key words: homoeostasis, electrolytes, immunostimulation.


Skripnik N. N., Ivanyura I. A., Razdaybedin V. N., Lysenko S. G., Boyarchuk E. D. Adaptation of the respiratory system to physical stress

The date was obtained to give information that physical activity influences the respiratory system. Disposition of the response for indicators of respiratory system depends on physical activity and starting condition of body and other physiological processes such as nervous processes and high nervous system. Analysis of processes of formation and appreciating adaptive capacity respiratory system for physical activity gives some information about rebuilding and mobilization of external respiration and physical reserve of mechanical ventilation.

^ Key words: athletes, physical activity, respiratory system.


Sokolenko V. L., Sokolenko S. V. Values of T-cellular immunityIn patients, who long lived inRadioactive contaminated territory

We studied the performance of T-cell immunity in people aged
19 – 20 years who resided since birth in areas contaminated with radionuclides. This pronounced dynamics of the absolute number of T lymphocytes in residents’ territories intensified radiological control, which would be confirmed statistically, from 1995 to 2010, not seen. Relative values of T-lymphocytes with phenotypes CD3 + and CD4 +, and immunoregulatory index CD4 +/ CD8+ show a tendency to slow recovery.

^ Key words: specific immunity, T-lymphocytes, small doses of radiation.


Fafula R. V., Lychkovska N. E., Efremova U. P., Vorobets Z. D.
Ca2+-Mg2+-ATP-ase enzyme activity in peripheral blood lymphocytes in patients with spondyloarthritis


The changes of Ca2+, Mg2+-ATP-ase enzyme activity of peripheral blood lymphocytes in patients with a spondyloarthritis have been studied. It showed the significant decrease of Ca2+, Mg2+- ATP-ase enzyme activity of lymphocyte plasma and endoplasmic reticulum membranes in patients with spondyloarthritis in comparison with the practically healthy donors. The dynamics of Сa2+, Mg2+- АТР-ase enzymatic activities is observed after patient’s treatment – enzyme activity approaches to its control value.

^ Key words: Ca2+, Mg2+-АТP-ase, spondyloarthritis, lymphocytes.


Khudyakova O. V. Anatomic changeability of structure of eye socket of people of ХХ of century

The variants of individual variableness of eye socket of people
of ХХ century are studied depending on the form of skull. It is set that the high form of eye socket prevailed at skulls, there were its extreme forms. A right eye socket had a large height, with counter-clockwise, and the width of right eye socket was practically identical with counter-clockwise.

Keywords: eye socket, individual variableness.


^ Chernyak Е. A., Avad Ali Riyadkh. Features of experimental design of saccharine diabetes

The resulted dynamics of level of glucose in the serum of experimental animals specifies on instability of model of diabetes mellitus in the first 21 days from the beginning of the experiment. At the increase of display experiment the level of glucose in the serum rose stably. Being based on findings, it is possible to draw a conclusion, that at the design of diabetes mellitus by introduction of Streptozotocin (SIGMA, the USA) in a dose
50 mgs/kg, stabilizing of model of diabetes mellitus takes place on 30th days from the beginning of the experiment.

^ Key words: experimental diabetes mellitus, Streptozotocin.


Sheiko V. I. The state of the neurodynamic functions and immune system during the Vilosenum appliance for the people with the myopia

The aim of our research was to study the neurodynamic functions and the state of the immune system on the background of the medium myopia and also to study the immunostimulation influence on the neurodynamic functions and the state of the immune system on the background of the myopia.

In the modern society a man is exposed to the stress influences among which the most widespread one is the informative (emotional information stress). We exposed that the medium myopia is accompanied by the functional tension of the immune system, namely by the cellular link secondary immunodeficiency, the improvement of the neurodynamic functions indexes (functional mobility of the nervous processes) is observed. The vilosenum appliance was accompanied by the latent periods increase of the simple sensor-motor reactions and by the indexes increase of the FMNP. The positive correlative relationship was exposed between the functional mobility of the nervous processes and the monocytes amount in the peripheral blood (r = 0,7). The same relationship was exposed between the functional mobility of the nervous processes and the T-suppressors amount in the peripheral blood (r = 0,6).

^ Key words: immune system, immunostimulation, functional mobility of the nervous processes, sensor-motor reactions.


Medical sciences

Vinogradov O. A. Experimental modeling of Traumatic Brain Injury

The review of methods of modeling traumatic brain injury available today is introduced in the article. Particular attention is given to experimental traumatic brain injury models in vivo, which provide the research using traditional laboratory animals, preferably rodents.

The review revealed that existing modeling methods enable today reproduce the certain details of the pathogenesis traumatic brain injury, with continued research questions require relating to the development of new and improvement of existing experimental traumatic brain injury models.

Key word: traumatic brain injury, modeling, experimental models in vivo.


Gavreluk S. V., Boyarchuk Е. D., Levenets S. V. The estimation of length of free lower limb for children of the period of the first childhood of the beginning of XXІ century by comparison to data of children of the beginning of XX century

The analysis of length of free lower limb and percent correlation of length of free lower limb to length of body for children of the period of the first childhood of the beginning of XXІ century by comparison to data of children of the beginning of XX century. The information can serve as foundation for development of normative documents of standards of physical development of children in Lugansk.

^ Key words: free lower limb.


Glazkov Е. А. To question of study of adaptation of students at studies in higher educational establishments

In the article the results of research of level of anxiety (situation, personality) are given in the process of studies for students by the standard method of Spilbergera. Adaptation possibilities of organism of students are certain in the process of studies in educational establishment and found out the psychological terms of adaptation of students-freshmen to the terms of studies. The comparative description of constituents of process of adaptation of students is given. The necessity of the research of the problem of adaptation and the correction of disorders of adaptation is certain in the process of studies.

^ Key words: adaptation of students, anxiety, disorders of adaptation.


Gromchenko Yu. А. GGT used for screening for viral hepatitis in prevention inspections

The article considers the relevance of viral hepatitis of early diagnosis, describes the point of the research with the use of GGT analysis among police officers during clinical examination in 2012. The high sensitivity of the analysis allows to use it in screening for hepatitis in prevention inspections.

^ Key words: viral hepatitis, hepatotoxicity, gamma-glutamyl transpeptidase (GGT), preventive inspection.


Knyshov G. V., Lazoryshynets V. V., Rudenko K. V.,
Rasputnyak O. V., Plyska A. I. A new in the clinical classification and strategy of treatment of the hypertrophic cardiomyopathy


Based on the analysis of the literature and our own research, a new classification of obstructive hypertrophic cardiomyopathy. Developed classifycation includes nonobstructive form (I (preclinical stage) – the absence of systolic pressure gradient (SPG), mitral regurgitation and electrophysiological changes (treatment – medication); II stage – SPG < 30 mm Hg, a minimal mitral regurgitation with initial electrophysiological changes labile and the primary clinical and hemodynamic manifestations (treatment – medication)) and the obstructive form (III stage – SPG > 30 mm Hg, moderate mitral regurgitation with persistent primary clinical manifestations (treatment – two-chamber pacing, alcohol septal ablation); IV stage – SPG > 30 mm Hg, expressed mitral insufficiency with persistent primary and secondary clinical and hemodynamic symptoms, progression of heart failure (treatment – surgery)).

^ Key words: hypertrophic cardiomyopathy, obstruction, outflow tract, stimulation and asymmetrical hypertrophy.


Resunenko Y. K., Prokopov V. A. State of enzyme systems bioenergetic processes in rats at conditions of prolonged influence of polyols structurally based on glycerol

Polyols which are structurally based on glycerol in 1/100 LD50 on the 30th day increase the activity of glucose-6-phosphate and isocitrate dehydrogenase on the background of decreasing of succinate dehydrogenase in the rat’s brain and liver. The activity of lactate dehydrogenase in these conditions increases in brain and decreases in liver. Polyols decrease the NADH-dependent malate dehydrogenase in liver and don’t influence the activity of the NADP-dependent form of this enzyme. Revealed changes show the decrease of energetic processes and the development of tissue hypoxia.

^ Key words: polyols, brain, liver, enzymes of energetic processes.


Savina A. V. Exposition dynamics of sorption of the liver in acute pancreatitis

In acute pancreatitis the exposition dynamics of sorption in the peripheral parts of the liver was greater than in the central, which is associated with large indicators initially. Accordingly, accurate assessment is to compare the changes detected sorption with controls.

^ Key words: acute pancreatitis, the exposition dynamics of sorption.


Tsarev A. A., Kosharny V. V., Abdul-Ogli L. V. The structural changes in limb muscles of rats with damage to the femoral and sciatic nerves

The aim of this study was to determine the changes occurring in the limbs of rats with damage to the femoral and sciatic nerves. After transactions of the sciatic nerve changes in the limbs there is a number of successive stages. We investigated the early changes in these conditions.

During the first hour with transaction of the sciatic nerve, there is the decrease of the specific mass of the muscle fibre and its reduction by the fourth hour of the experiment by cutting the femoral nerve changes in the muscles of the front panel. There are similar changes in the back of the thigh muscles and occur in the same sequence. When the femoral nerve transaction diameter of the arterioles to the fourth hour of the experiment is increased 1,3 times and 1,7 times in venues. The diameter of the capillaries does not change.

Key words: femoral nerve, sciatic nerve, rat.

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